Automated Planning Enables Complex Protocols on Liquid-Handling Robots

ACS Synthetic Biology
Ellis WhiteheadJörg Stelling

Abstract

Robotic automation in synthetic biology is especially relevant for liquid handling to facilitate complex experiments. However, research tasks that are not highly standardized are still rarely automated in practice. Two main reasons for this are the substantial investments required to translate molecular biological protocols into robot programs, and the fact that the resulting programs are often too specific to be easily reused and shared. Recent developments of standardized protocols and dedicated programming languages for liquid-handling operations addressed some aspects of ease-of-use and portability of protocols. However, either they focus on simplicity, at the expense of enabling complex protocols, or they entail detailed programming, with corresponding skills and efforts required from the users. To reconcile these trade-offs, we developed Roboliq, a software system that uses artificial intelligence (AI) methods to integrate (i) generic formal, yet intuitive, protocol descriptions, (ii) complete, but usually hidden, programming capabilities, and (iii) user-system interactions to automatically generate executable, optimized robot programs. Roboliq also enables high-level specifications of complex tasks with conditional execu...Continue Reading

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Citations

Mar 3, 2019·Proceedings of the National Academy of Sciences of the United States of America·Peter WashingtonIngmar H Riedel-Kruse
Apr 17, 2020·PloS One·Loïc M RochAlán Aspuru-Guzik
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Jun 18, 2021·Physical Review. E·Alidivinas PrusokasRenata Retkute
Sep 25, 2021·Microbial Cell Factories·Kaushik RajRadhakrishnan Mahadevan

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