Automated Quantification of Capillary Nonperfusion Using Optical Coherence Tomography Angiography in Diabetic Retinopathy

JAMA Ophthalmology
Thomas S HwangYali Jia

Abstract

Macular ischemia is a key feature of diabetic retinopathy (DR). Quantification of macular ischemia has potential as a biomarker for DR. To assess the feasibility of automated quantification of capillary nonperfusion as a potential sign of macular ischemia using optical coherence tomography (OCT) angiography. An observational study conducted in a tertiary, subspecialty, academic practice evaluated macular nonperfusion with 6 × 6-mm OCT angiography obtained with commercially available 70-kHz OCT and fluorescein angiography (FA). The study was conducted from January 22 to September 18, 2014. Data analysis was performed from October 1, 2014, to April 7, 2015. Participants included 12 individuals with normal vision serving as controls and 12 patients with various levels of DR. Preplanned primary measures were parafoveal and perifoveal vessel density, total avascular area, and foveal avascular zone as detected with 6 × 6-mm OCT angiography and analyzed using an automated algorithm. Secondary measures included the agreement of the avascular area between the OCT angiogram and FA. Compared with the 12 healthy controls (11 women; mean [SD] age, 54.2 [14.2] years), the 12 participants with DR (4 women; mean [SD] age, 55.1 [12.1] years) ha...Continue Reading

Citations

May 14, 2016·Expert Review of Medical Devices·Rupesh AgrawalAniruddha Agarwal
Sep 16, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Eduardo A NovaisJay S Duker
Oct 21, 2016·Journal of Diabetes Research·Pedro Romero-ArocaRaquel Verges
Dec 16, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Colin S TanSriniVas R Sadda
Jun 12, 2017·Vision Research·Peter L NesperAmani A Fawzi
Mar 9, 2017·Biomedical Optics Express·Changlei DongyeYali Jia
Mar 21, 2018·European Journal of Ophthalmology·Salomon Y CohenSarah Mrejen
Feb 13, 2018·Asia-Pacific Journal of Ophthalmology·Chris OrNadia Waheed
May 15, 2018·Current Eye Research·Sunee Chansangpetch, Shan C Lin
Dec 3, 2017·Scientific Reports·Ian J C MacCormickGabriela Czanner
Jul 17, 2018·Translational Vision Science & Technology·Brian D KrawitzToco Y P Chui
Mar 8, 2017·Journal of Biomedical Optics·Morgan HeislerMarinko V Sarunic
Jul 13, 2016·Journal of Biomedical Optics·Pavle PrentašicSven Loncaric
Oct 4, 2018·Translational Vision Science & Technology·Rachel E LindermanJoseph Carroll
Mar 13, 2019·European Journal of Ophthalmology·José Ignacio Fernández-VigoJosé Ángel Fernández-Vigo
Nov 16, 2016·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Mastour A AlhamamiMasahiro Miura
Aug 31, 2016·International Ophthalmology Clinics·Muhammad HassanDiana V Do
Apr 2, 2019·Investigative Ophthalmology & Visual Science·William W Binotti, Andre C Romano
Jan 22, 2020·Experimental Biology and Medicine·Xincheng YaoDevrim Toslak
Dec 22, 2016·Retina·Moncef KhairallahSalim Ben Yahia
Mar 4, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Muhammet Furkan KorkmazElif Güler Kazancı
Jan 15, 2020·Der Ophthalmologe : Zeitschrift der Deutschen Ophthalmologischen Gesellschaft·UNKNOWN Deutsche Ophthalmologische Gesellschaft (DOG)UNKNOWN Berufsverband der Augenärzte Deutschlands e. V. (BVA)
Jan 8, 2020·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Peter M MalocaUNKNOWN IOB study group

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.