Automated quantitative 3D analysis of aorta size, morphology, and mural calcification distributions

Medical Physics
Sila KurugolRaul San Jose Estepar

Abstract

The purpose of this work is to develop a fully automated pipeline to compute aorta morphology and calcification measures in large cohorts of CT scans that can be used to investigate the potential of these measures as imaging biomarkers of cardiovascular disease. The first step of the automated pipeline is aorta segmentation. The algorithm the authors propose first detects an initial aorta boundary by exploiting cross-sectional circularity of aorta in axial slices and aortic arch in reformatted oblique slices. This boundary is then refined by a 3D level-set segmentation that evolves the boundary to the location of nearby edges. The authors then detect the aortic calcifications with thresholding and filter out the false positive regions due to nearby high intensity structures based on their anatomical location. The authors extract the centerline and oblique cross sections of the segmented aortas and compute the aorta morphology and calcification measures of the first 2500 subjects from COPDGene study. These measures include volume and number of calcified plaques and measures of vessel morphology such as average cross-sectional area, tortuosity, and arch width. The authors computed the agreement between the algorithm and expert se...Continue Reading

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Citations

Jan 24, 2019·European Radiology·Zahra Sedghi GamechiMarleen de Bruijne
Sep 24, 2018·International Journal of Computer Assisted Radiology and Surgery·Pablo G TahocesJosé M Carreira
Feb 20, 2020·Medical & Biological Engineering & Computing·Pablo G TahocesJose M Carreira
Jan 12, 2021·Journal of Magnetic Resonance Imaging : JMRI·Thomas DietenbeckNadjia Kachenoura
Feb 26, 2020·Journal of Vascular Surgery·Juliette RaffortFabien Lareyre
Mar 30, 2021·Radiology. Cardiothoracic Imaging·Lewis D HahnDominik Fleischmann
Dec 21, 2019·Annals of Vascular Surgery·Juliette RaffortFabien Lareyre
Jun 18, 2021·Computers in Biology and Medicine·Pablo G TahocesJose M Carreira

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