PMID: 9163584May 1, 1997Paper

Automated red cell exchange in sickle cell disease

British Journal of Haematology
S L JanesD H Bevan

Abstract

Red cell exchange is important in the care of acutely ill sickle-cell patients, and may be life-saving. An automated red cell exchange technique has been developed using a Baxter blood cell separator, enabling an isovolaemic exchange to be performed within 2.5 h. A total of 20 procedures have been performed in 15 patients, including one woman in the third trimester of pregnancy, with a mean decrease of 72% in the circulating sickle haemoglobin (HbS) level. This method enables almost all adult patients with sickle cell anaemia to have their HbS reduced to safe levels by only one procedure. The procedure was well tolerated by all patients, including those who were acutely ill. This technique provides an effective procedure for reducing the percentage of circulating HbS rapidly in acutely ill patients with complications of sickle cell anaemia.

Citations

Jan 17, 2017·British Journal of Haematology·Bernard A DavisUNKNOWN British Committee for Standards in Haematology
May 26, 1999·Clinical and Laboratory Haematology·S E LawsonD Bareford
Dec 29, 2000·Transactions of the Royal Society of Tropical Medicine and Hygiene·D C MacallanD H Bevan
Mar 27, 2015·Journal of Clinical Apheresis·Samir K Ballas, David Lyon

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