Automated, reference-free local error assessment of multimodal deformable image registration for radiotherapy in the head and neck

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
Michael G NixRichard Speight

Abstract

Head and neck MR-CT deformable image registration (DIR) for radiotherapy planning is hindered by the lack of both ground-truth and per-patient accuracy assessment methods. This study assesses novel post-registration reference-free error assessment algorithms, based on local rigid re-registration of native and pseudomodality images. Head and neck MR obtained in and out of the treatment position underwent DIR to planning CT. Block-wise mutual information (b-MI) and pseudomodality mutual information (b-pmMI) algorithms were validated against applied rotations and translations. Inherent registration error detection was compared across 14 patient datasets. Using radiotherapy position MR-CT DIR, quantitative comparison of applied rotations and translations revealed that errors between 1 and 4 mm were accurately determined by both algorithms. Using diagnostic position MR-CT DIR, translations of up to 5 mm were accurately detected within the gross tumour volume by both methods. In 14 patient datasets, b-MI and b-pmMI detected similar errors with improved stability in regions of low contrast or CT artefact and a 10-fold speedup for b-pmMI. b-MI and b-pmMI algorithms have been validated as providing accurate reference-free quantitative a...Continue Reading

Citations

May 22, 2019·The British Journal of Radiology·Daniel JarrettMark J Gooding
Aug 3, 2020·Journal of Medical Radiation Sciences·Jeffrey BarberDavid Thwaites
Jan 28, 2022·Journal of Applied Clinical Medical Physics·Chunling JiangYun Zhang

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