Automated Retinal Layer Segmentation Using Graph-based Algorithm Incorporating Deep-learning-derived Information.

Scientific Reports
Zubin MishraZhihong Hu

Abstract

Regular drusen, an accumulation of material below the retinal pigment epithelium (RPE), have long been established as a hallmark early feature of nonneovascular age-related macular degeneration (AMD). Advances in imaging have expanded the phenotype of AMD to include another extracellular deposit, reticular pseudodrusen (RPD) (also termed subretinal drusenoid deposits, SDD), which are located above the RPE. We developed an approach to automatically segment retinal layers associated with regular drusen and RPD in spectral domain (SD) optical coherence tomography (OCT) images. More specifically, a shortest-path algorithm enhanced with probability maps generated through a fully convolutional neural network was used to segment drusen and RPD, as well as 11 retinal layers in SD-OCT volumes. This algorithm achieves a mean difference that is within the subpixel accuracy range drusen and RPD, alongside the other 11 retinal layers, highlighting the high robustness of this algorithm for this dataset. To the best of our knowledge, this is the first report of a validated algorithm for the automated segmentation of the retinal layers including early AMD features of RPD and regular drusen separately on SD-OCT images.

References

Nov 16, 2005·Archives of Ophthalmology·Frederick L FerrisUNKNOWN Age-Related Eye Disease Study (AREDS) Research Group
Jan 13, 2006·IEEE Transactions on Pattern Analysis and Machine Intelligence·Kang LiMilan Sonka
Oct 3, 2006·American Journal of Ophthalmology·Ronald KleinRonald E Gangnon
Jan 24, 2007·American Journal of Ophthalmology·Frank G HolzUNKNOWN FAM-Study Group
Nov 27, 2007·Progress in Retinal and Eye Research·Wolfgang Drexler, James G Fujimoto
Jun 17, 2008·Investigative Ophthalmology & Visual Science·Michael A SandbergEliot L Berson
Mar 13, 2009·IEEE Transactions on Medical Imaging·Mona Kathryn GarvinMilan Sonka
Oct 10, 2009·Ophthalmology·Sandrine A ZweifelYutaka Imamura
Jan 19, 2010·Ophthalmology·Catherine CukrasUNKNOWN Age-Related Eye Disease Study Research Group
Jan 1, 2009·Medical Image Computing and Computer-assisted Intervention : MICCAI·Azadeh YazdanpanahMarinko Sarunic
Jun 23, 2011·Investigative Ophthalmology & Visual Science·Mahsa A SohrabAmani A Fawzi
Nov 1, 2011·Investigative Ophthalmology & Visual Science·Stephanie J ChiuSina Farsiu
Jan 24, 2012·Investigative Ophthalmology & Visual Science·Giuseppe QuerquesEric H Souied
Jan 26, 2013·Investigative Ophthalmology & Visual Science·Zhihong HuSrinivas R Sadda
Apr 16, 2013·Retina·Carlos Alexandre de Amorim Garcia FilhoPhilip J Rosenfeld
Jul 25, 2013·Medical Image Analysis·Qiang ChenDaniel L Rubin
Sep 3, 2013·Ophthalmology·Sina FarsiuUNKNOWN Age-Related Eye Disease Study 2 Ancillary Spectral Domain Optical Coherence Tomography Study Group
Oct 12, 2013·Investigative Ophthalmology & Visual Science·Marcela MarsigliaR Theodore Smith
Nov 12, 2013·Progress in Retinal and Eye Research·Yogesan KanagasingamTien Y Wong
Nov 22, 2018·Biomedical Optics Express·Jason KugelmanMichael J Collins

❮ Previous
Next ❯

Citations

Jan 23, 2022·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Matthias GutfleischDaniel Pauleikhoff

❮ Previous
Next ❯

Methods Mentioned

BETA
imaging technique
RAP

Software Mentioned

Net
MATLAB
SP
DL
mathop

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.