Automated segmentation of foveal avascular zone in fundus fluorescein angiography

Investigative Ophthalmology & Visual Science
Yalin ZhengSimon P Harding

Abstract

PURPOSE. To describe and evaluate the performance of a computerized automated segmentation technique for use in quantification of the foveal avascular zone (FAZ). METHODS. A computerized technique for automated segmentation of the FAZ using images from fundus fluorescein angiography (FFA) was applied to 26 transit-phase images obtained from patients with various grades of diabetic retinopathy. The area containing the FAZ zone was first extracted from the original image and smoothed by a Gaussian kernel (sigma = 1.5). An initializing contour was manually placed inside the FAZ of the smoothed image and iteratively moved by the segmentation program toward the FAZ boundary. Five tests with different initializing curves were run on each of 26 images to assess reproducibility. The accuracy of the program was also validated by comparing results obtained by the program with the FAZ boundaries manually delineated by medical retina specialists. Interobserver performance was then evaluated by comparing delineations from two of the experts. RESULTS. One-way analysis of variance indicated that the disparities between different tests were not statistically significant, signifying excellent reproducibility for the computer program. There was ...Continue Reading

Citations

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Feb 16, 2016·Ophthalmic Surgery, Lasers & Imaging Retina·Di GongFangtian Dong
Mar 19, 2013·Progress in Retinal and Eye Research·Jan M ProvisJoseph Carroll
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Sep 8, 2015·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·Gong DiDong Fangtian
Apr 8, 2014·Progress in Retinal and Eye Research·Rainer A LeitgebLeopold Schmetterer
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