Automated software for analysis of ciliary beat frequency and metachronal wave orientation in primary ciliary dyskinesia.

European Archives of Oto-rhino-laryngology : Official Journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : Affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
Giulia MantovaniGiovanni Vozzi

Abstract

Patients with primary ciliary dyskinesia (PCD) have structural and/or functional alterations of cilia that imply deficits in mucociliary clearance and different respiratory pathologies. A useful indicator for the difficult diagnosis is the ciliary beat frequency (CBF) that is significantly lower in pathological cases than in physiological ones. The CBF computation is not rapid, therefore, the aim of this study is to propose an automated method to evaluate it directly from videos of ciliated cells. The cells are taken from inferior nasal turbinates and videos of ciliary movements are registered and eventually processed by the developed software. The software consists in the extraction of features from videos (written with C++ language) and the computation of the frequency (written with Matlab language). This system was tested both on the samples of nasal cavity and software models, and the results were really promising because in a few seconds, it can compute a reliable frequency if compared with that measured with visual methods. It is to be noticed that the reliability of the computation increases with the quality of acquisition system and especially with the sampling frequency. It is concluded that the developed software coul...Continue Reading

References

Dec 13, 1990·The New England Journal of Medicine·J Rutland, R U de Iongh
Mar 1, 1986·Medical & Biological Engineering & Computing·H TeichtahlR L Kirsner
Apr 1, 1993·The American Review of Respiratory Disease·F VerraE Escudier
Mar 1, 1997·Chest·C Clary-MeineszB Blaive
Nov 17, 1998·The European Respiratory Journal·A BushJ O Warner
Dec 12, 2001·Pediatric Allergy and Immunology : Official Publication of the European Society of Pediatric Allergy and Immunology·M PifferiA L Boner
Aug 2, 2003·Medical & Biological Engineering & Computing·W J YiC S Rhee
Jan 16, 2007·Current Opinion in Allergy and Clinical Immunology·Marcelo B Antunes, Noam A Cohen
Jul 20, 2007·Archives of Disease in Childhood·Andrew BushGill Phillips
Mar 14, 2008·International Journal of Immunopathology and Pharmacology·M PifferiA L Boner
Mar 25, 2008·The Pediatric Infectious Disease Journal·Massimo PifferiAttilio L Boner

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Citations

Feb 8, 2011·Genes to Cells : Devoted to Molecular & Cellular Mechanisms·Dongbo ShiToshihiko Fujimori
Aug 8, 2015·Science Translational Medicine·Shannon P QuinnS Chakra Chennubhotla
Jan 21, 2014·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Eduardo ParrillaDavid Moratal
Nov 21, 2018·American Journal of Rhinology & Allergy·Eduardo ParrillaJaime Riera
Jul 18, 2019·Pediatric Pulmonology·Céline KempeneersMark A Chilvers
Feb 28, 2019·Frontiers in Genetics·Peishan ZhangErica A Golemis

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