Automated spectroscopic retinal oximetry with visible-light optical coherence tomography.

Biomedical Optics Express
Shaohua PiYali Jia

Abstract

Accurate, quantitative assessment of retinal blood oxygen saturation (sO2 ) may provide a useful early indicator of pathophysiology in several ocular diseases. Here, with visible-light optical coherence tomography (OCT), we demonstrate an automated spectroscopic retinal oximetry algorithm to measure the sO2 within the retinal arteries (A-sO2 ) and veins (V-sO2 ) in rats by automatically detecting the vascular posterior boundary on cross-sectional structural OCT. The algorithm was validated in vitro with flow phantoms and in vivo in rats by comparing the sO2 results, respectively, to those obtained using a blood gas analyzer and pulse oximetry. We also investigated the response of oxygen extraction (A-V sO2 ), including inter-session reproducibility, at different inhaled oxygen concentrations.

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Citations

May 16, 2019·Experimental Biology and Medicine·Taeyoon SonXincheng Yao
Jan 18, 2019·Light, Science & Applications·James A WinkelmannVadim Backman
Apr 3, 2020·Optics Letters·Kevin C ZhouJoseph A Izatt
May 14, 2020·Proceedings of the National Academy of Sciences of the United States of America·Shaohua PiYali Jia
Jul 2, 2019·Biomedical Optics Express·Tingwei ZhangVivek J Srinivasan
Nov 23, 2020·Experimental Eye Research·Matthew P Nicholas, Naveen Mysore
May 19, 2021·Translational Vision Science & Technology·Anupam K GargDaniel L Chao
May 18, 2021·Biomedical Optics Express·Xiang WeiYali Jia
Jul 10, 2021·Annual Review of Vision Science·Alexi GeevargheseJoel S Schuman

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