Automatic Adaptation of Basal Insulin Using Sensor-Augmented Pump Therapy

Journal of Diabetes Science and Technology
Pau HerreroPantelis Georgiou

Abstract

People with insulin-dependent diabetes rely on an intensified insulin regimen. Despite several guidelines, they are usually impractical and fall short in achieving optimal glycemic outcomes. In this work, a novel technique for automatic adaptation of the basal insulin profile of people with diabetes on sensor-augmented pump therapy is presented. The presented technique is based on a run-to-run control law that overcomes some of the limitations of previously proposed methods. To prove its validity, an in silico validation was performed. Finally, the artificial intelligence technique of case-based reasoning is proposed as a potential solution to deal with variability in basal insulin requirements. Over a period of 4 months, the proposed run-to-run control law successfully adapts the basal insulin profile of a virtual population (10 adults, 10 adolescents, and 10 children). In particular, average percentage time in target [70, 180] mg/dl was significantly improved over the evaluated period (first week versus last week): 70.9 ± 11.8 versus 91.1 ± 4.4 (adults), 46.5 ± 11.9 versus 80.1 ± 10.9 (adolescents), 49.4 ± 12.9 versus 73.7 ± 4.1 (children). Average percentage time in hypoglycemia (<70 mg/dl) was also significantly reduced: 9....Continue Reading

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Citations

Jun 2, 2020·Journal of Diabetes Science and Technology·Darpit DaveMadhav Erraguntla
Jun 11, 2020·Sensors·Nichole S Tyler, Peter G Jacobs
Jul 23, 2020·Nature Metabolism·Nichole S TylerPeter G Jacobs
Sep 29, 2019·Journal of Diabetes Science and Technology·Iman HajizadehAli Cinar
Dec 1, 2020·Journal of Diabetes Science and Technology·Michael A NauckJuris J Meier

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