Automatic analysis of cross-sectional cerebral asymmetry on 3D in vivo MRI scans of human and chimpanzee

Journal of Neuroscience Research
Li XiangNeil Roberts

Abstract

One prominent feature of human brain asymmetry is the cerebral torque. To investigate whether this characteristic is shared with chimpanzees who are our closest extant relative, we developed an automatic method to compute cerebral hemisphere width and perimeter length on consecutive 2D sections through 3D MR images obtained in vivo for 91 human and 78 chimpanzee brains. In brief, contiguous inter-hemispheric width and perimeter asymmetries were calculated on coronal sections, which in profile allow us to examine asymmetry in relation to speciation. The right frontal and left occipital asymmetry (greater posteriorly in females) distinguishes humans from chimpanzees. This result is consistent with a major saltational (discontinuity) event occurring at some point after the separation of humanity and the great apes in the last 6 million years.

References

Feb 24, 1978·Science·A M GalaburdaN Geschwind
Jan 1, 1976·Annals of the New York Academy of Sciences·M LeMay
Jul 1, 1976·Neurology·A B RubensJ T Hutton
Jul 12, 1968·Science·N Geschwind, W Levitsky
May 1, 1982·American Journal of Physical Anthropology·R L Holloway, M C De La Costelareymondie
Jan 1, 1996·Neuroscience and Biobehavioral Reviews·K ZillesH Steinmetz
Apr 29, 1998·Schizophrenia Research·R Guerguerian, R R Lewine
Jan 4, 2003·Nature Reviews. Neuroscience·Arthur W Toga, Paul M Thompson
Jun 15, 2004·NeuroImage·E LudersG Schlaug
Feb 22, 2005·Schizophrenia Research·Steven A ChanceTimothy J Crow
Aug 18, 2005·Proceedings of the National Academy of Sciences of the United States of America·Elizabeth V Lonsdorf, William D Hopkins
Jul 1, 2008·NeuroImage·William D HopkinsChet C Sherwood
Apr 18, 2014·Brain : a Journal of Neurology·Jerome J MallerPaul B Fitzgerald
Apr 14, 2016·The Australian and New Zealand Journal of Psychiatry·Jerome J MallerPaul B Fitzgerald
Oct 17, 2017·NeuroImage·Xiang LiNeil Roberts
May 17, 2018·Proceedings of the National Academy of Sciences of the United States of America·Xiang-Zhen KongClyde Francks
Jan 13, 2019·Brain Structure & Function·Li XiangNeil Roberts

❮ Previous
Next ❯

Citations


❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.