Automatic classification and analysis of microneurographic spike data using a PC/AT

Journal of Neuroscience Methods
C Forster, H O Handwerker

Abstract

Using a standard PC-AT with a commercial analog data interface a system was designed which supports microneurographic experiments and which may also be used for other types of extracellular spike recordings. The signal is sampled on-line at 25 kHz and a spike is detected if the signal passes a certain threshold. The spikes are displayed on the screen and stored on disk. A second on-line mode records the responses of the examined unit to electrical stimulations, which are used to identify the type of fibre and to test the subsequent spike classification. The spikes are classified off-line using a template matching algorithm, which has unsupervised learning and discrimination phases. The results are displayed in a time-frequency plot and may be checked with the responses to electrical stimulations. Artifacts from EMG and other electrical fields are reliably sorted out. In recordings, which include more than one unit, their spikes are discriminated with a low error rate.

References

Aug 1, 1979·Electroencephalography and Clinical Neurophysiology·J F Vibert, J Costa
May 1, 1975·Medical & Biological Engineering·W WiemerH Klatt
Jun 1, 1988·Journal of Neuroscience Methods·B B EdinL O Bäckström
Jul 1, 1987·Medical & Biological Engineering & Computing·J F VibertJ Costa
May 15, 1986·Neuroscience Letters·Peter W Reeh
Aug 1, 1986·Journal of Neuroscience Methods·F WörgötterR Eckmiller
Jan 1, 1986·Medical & Biological Engineering & Computing·J Costa, J F Vibert
Jan 1, 1973·Electroencephalography and Clinical Neurophysiology·W H Calvin
Jan 1, 1967·Acta Physiologica Scandinavica·K E Hagbarth, A B Vallbo
Jun 1, 1983·IEEE Transactions on Bio-medical Engineering·A Cohen, D Landsberg
Apr 1, 1982·Computer Programs in Biomedicine·M Okada, N Maruyama
Dec 1, 1982·IEEE Transactions on Bio-medical Engineering·B C Wheeler, W J Heetderks

Citations

Sep 1, 1992·Medical & Biological Engineering & Computing·H Bakardjian
Mar 24, 2000·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·J F AntogniniE Carstens
Nov 17, 2006·Experimental Brain Research·Kayoko Hasegawa, Hisashi Ogawa
May 1, 2009·Experimental Brain Research·Michael St PierreKatharina Zimmermann
Aug 1, 1990·Journal of Neuroscience Methods·J H Cocatre-Zilgien, F Delcomyn
Feb 1, 1992·Journal of Neuroscience Methods·R F Jansen, A Ter Maat
Apr 1, 1995·Journal of Neuroscience Methods·B E Peterson, M M Merzenich
Dec 1, 1995·Journal of Neuroscience Methods·F Marion-Poll
Jun 27, 1997·Journal of Neuroscience Methods·S C Gandevia, J P Hales
Oct 16, 1999·Journal of Neuroscience Methods·K S Guillory, R A Normann
Feb 25, 1998·Brain Research. Brain Research Protocols·R G Hallin, G Wu
May 1, 1997·International Journal of Medical Informatics·E SotoR Vega
Aug 10, 2002·Clinical Neurophysiology : Official Journal of the International Federation of Clinical Neurophysiology·Mitsuhiro WatanabeHideshige Moriya
Jan 31, 2009·Nature Protocols·Katharina ZimmermannPeter W Reeh
Sep 13, 2001·The European Journal of Neuroscience·Gábor PethoPeter W Reeh
Sep 28, 1998·The European Journal of Neuroscience·D L BennettS B McMahon
Apr 24, 1999·The European Journal of Neuroscience·M KoltzenburgS B McMahon
Oct 6, 1999·The European Journal of Neuroscience·S GuentherMichaela Kress
Jun 8, 2001·European Journal of Pain : EJP·W KoppertPeter W Reeh
Mar 20, 2004·Cephalalgia : an International Journal of Headache·A EbersbergerFrank Richter
Feb 11, 2003·The Journal of Physiology·C WeidnerH O Handwerker
Jan 24, 2009·Journal of Neurophysiology·Carolyn M SawyerE Carstens
Oct 23, 2013·Antioxidants & Redox Signaling·Maike KanngiesserIrmgard Tegeder

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