Automatic Coronary Calcium Scoring in Non-Contrast-Enhanced ECG-Triggered Cardiac CT With Ambiguity Detection

IEEE Transactions on Medical Imaging
Jelmer M WolterinkIvana Isgum

Abstract

The amount of coronary artery calcification (CAC) is a strong and independent predictor of cardiovascular events. We present a system that automatically quantifies total patient and per coronary artery CAC in non-contrast-enhanced, ECG-triggered cardiac CT. The system identifies candidate calcifications that cannot be automatically labeled with high certainty and optionally presents these to an expert for review. Candidates were extracted by intensity-based thresholding and described by location features derived from estimated coronary artery positions, as well as size, shape and intensity features. Next, a two-class classifier distinguished between coronary calcifications and negatives or a multiclass classifier labeled CAC per coronary artery. Candidates that could not be labeled with high certainty were identified by entropy-based ambiguity detection and presented to an expert for review and possible relabeling. The system was evaluated with 530 test images. Using the two-class classifier, the intra-class correlation coefficient (ICC) between reference and automatically determined total patient CAC volume was 0.95. Using the multiclass classifier, the ICC between reference and automatically determined per artery CAC volume w...Continue Reading

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Citations

May 6, 2016·Medical Physics·Guanyu YangJean-Louis Coatrieux
Apr 6, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Ivana IšgumPiotr J Slomka
Feb 7, 2018·IEEE Transactions on Medical Imaging·Nikolas LessmannIvana Isgum
Jun 3, 2017·IEEE Transactions on Medical Imaging·Jelmer M WolterinkIvana Isgum
Nov 8, 2018·Echo Research and Practice·Maryam AlsharqiPaul Leeson
Nov 16, 2019·European Radiology·Mårten SandstedtAnders Persson
Jun 9, 2020·Expert Review of Medical Devices·Andrew LinDamini Dey
Jul 26, 2017·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Shifali Dumeer, Andrew J Einstein
Aug 11, 2019·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·K R SiegersmaJ W Verjans
Mar 27, 2019·Journal of Medical Systems·Chen DatongLin Yueming
Feb 11, 2020·Frontiers in Cardiovascular Medicine·Nils HampeIvana Išgum
Jul 6, 2020·The International Journal of Cardiovascular Imaging·Verena BrandtChristian Tesche
Aug 10, 2019·JACC. Cardiovascular Imaging·Geert LitjensIvana Išgum
Feb 6, 2021·Diagnostics·Gurpreet Singh On Behalf Of The Credence And Iconic Investigators
Oct 11, 2020·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Azadeh AbravanEliana M Vasquez Osorio
Mar 30, 2021·Radiology. Cardiothoracic Imaging·Andrew LinDamini Dey
Apr 5, 2021·Journal of Cardiovascular Computed Tomography·Andrew LinDamini Dey
Feb 3, 2021·EuroIntervention : Journal of EuroPCR in Collaboration with the Working Group on Interventional Cardiology of the European Society of Cardiology·Miao ChuShengxian Tu
Jul 9, 2021·Radiology. Cardiothoracic Imaging·Peter I KamelCheng Ting Lin
Jul 30, 2021·European Heart Journal Cardiovascular Imaging·David J WinkelSaikiran Rapaka
Aug 18, 2021·Korean Journal of Radiology : Official Journal of the Korean Radiological Society·June-Goo LeeDong Hyun Yang

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