Automatic Detection of Cerebral Microbleeds From MR Images via 3D Convolutional Neural Networks

IEEE Transactions on Medical Imaging
Qi Dou Pheng-Ann Heng

Abstract

Cerebral microbleeds (CMBs) are small haemorrhages nearby blood vessels. They have been recognized as important diagnostic biomarkers for many cerebrovascular diseases and cognitive dysfunctions. In current clinical routine, CMBs are manually labelled by radiologists but this procedure is laborious, time-consuming, and error prone. In this paper, we propose a novel automatic method to detect CMBs from magnetic resonance (MR) images by exploiting the 3D convolutional neural network (CNN). Compared with previous methods that employed either low-level hand-crafted descriptors or 2D CNNs, our method can take full advantage of spatial contextual information in MR volumes to extract more representative high-level features for CMBs, and hence achieve a much better detection accuracy. To further improve the detection performance while reducing the computational cost, we propose a cascaded framework under 3D CNNs for the task of CMB detection. We first exploit a 3D fully convolutional network (FCN) strategy to retrieve the candidates with high probabilities of being CMBs, and then apply a well-trained 3D CNN discrimination model to distinguish CMBs from hard mimics. Compared with traditional sliding window strategy, the proposed 3D FCN ...Continue Reading

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Citations

Aug 5, 2016·NeuroImage. Clinical·T L A van den HeuvelB Platel
Dec 28, 2016·IEEE Transactions on Medical Imaging·Lequan YuPheng-Ann Heng
Apr 4, 2017·IEEE Transactions on Cybernetics·Hao ChenPheng-Ann Heng
Aug 25, 2017·Journal of Magnetic Resonance Imaging : JMRI·Takahiro NakaoOsamu Abe
Feb 23, 2018·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society·Jun-Yan HeRamesh Jain
Feb 9, 2018·AJNR. American Journal of Neuroradiology·G ZaharchukC P Langlotz
May 24, 2017·IEEE Journal of Biomedical and Health Informatics·Zhen YuTianfu Wang
Nov 14, 2017·Radiographics : a Review Publication of the Radiological Society of North America, Inc·Gabriel ChartrandAn Tang
Jan 24, 2017·IEEE Transactions on Bio-medical Engineering·Qi DouPheng-Ann Heng
Oct 6, 2017·AJR. American Journal of Roentgenology·Daniel ChowChristopher G Filippi
Feb 7, 2018·Journal of Digital Imaging·Simukayi MutasaRama Ayyala
Oct 28, 2018·Medical Physics·Berkman SahinerMaryellen L Giger
Apr 13, 2019·Journal of Computational Biology : a Journal of Computational Molecular Cell Biology·Xi HuXiaoming Wu
Jul 2, 2019·Current Opinion in Obstetrics & Gynecology·Gaby MoawadMichelle Louie
Aug 28, 2019·Journal of Digital Imaging·Hiroki KobayashiHajime Sakuma
Nov 2, 2019·Medical Physics·Dooman ArefanShandong Wu
Jan 30, 2019·Canadian Association of Radiologists Journal = Journal L'Association Canadienne Des Radiologistes·Sabeena JalalWilliam Parker
Dec 21, 2019·Physics in Medicine and Biology·Maryam GolshanIngrid Spadinger
Nov 28, 2019·Australasian Physical & Engineering Sciences in Medicine·Naoki MatsubaraHiroshi Fujita
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Jan 4, 2019·Journal of Cancer Research and Clinical Oncology·Pandia Rajan Jeyaraj, Edward Rajan Samuel Nadar
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Jun 18, 2017·Current Treatment Options in Cardiovascular Medicine·Gordon W BlairJoanna M Wardlaw

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