Apr 18, 2020

Automatic Landmark-guided Bijective Brain Image Registration by Composing Region-based Locally Diffeomorphic Warpings

BioRxiv : the Preprint Server for Biology
He, Q. R. Razlighi


As the size of the neuroimaging cohorts being increased to address key questions in the field of cognitive neuroscience, cognitive aging, and neurodegenerative diseases, the accuracy of the spatial normalization as an essential pre-processing step becomes extremely important in the neuroimaging processing pipeline. Existing spatial normalization methods have poor accuracy particularly when dealing with the highly convoluted human cerebral cortex and when brain morphology is severely altered (e.g. clinical and aging populations). To address this shortcoming, we propose to implement and evaluate a novel landmark-guided region-based spatial normalization technique that takes advantage of the existing surface-based human brain parcellation to automatically identify and match regional landmarks. To simplify the non-linear whole brain registration, the identified landmarks of each region and their counterparts are registered independently with large diffeomorphic (topology preserving) deformation via geodesic shooting. The regional diffeomorphic warping fields were combined by an inverse distance weighted interpolation technique to have a smooth global warping field for the whole brain. To ensure that the final warping field is diffe...Continue Reading

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