Automatic localization of the prostate for on-line or off-line image-guided radiotherapy

International Journal of Radiation Oncology, Biology, Physics
Monique H P SmitsmansMarcel van Herk

Abstract

With higher radiation dose, higher cure rates have been reported in prostate cancer patients. The extra margin needed to account for prostate motion, however, limits the level of dose escalation, because of the presence of surrounding organs at risk. Knowledge of the precise position of the prostate would allow significant reduction of the treatment field. Better localization of the prostate at the time of treatment is therefore needed, e.g. using a cone-beam computed tomography (CT) system integrated with the linear accelerator. Localization of the prostate relies upon manual delineation of contours in successive axial CT slices or interactive alignment and is fairly time-consuming. A faster method is required for on-line or off-line image-guided radiotherapy, because of prostate motion, for patient throughput and efficiency. Therefore, we developed an automatic method to localize the prostate, based on 3D gray value registration. A study was performed on conventional repeat CT scans of 19 prostate cancer patients to develop the methodology to localize the prostate. For each patient, 8-13 repeat CT scans were made during the course of treatment. First, the planning CT scan and the repeat CT scan were registered onto the rigid ...Continue Reading

References

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Citations

May 26, 2011·Investigative Radiology·Johannes G KorporaalUulke A van der Heide
Dec 9, 2008·Clinical Oncology : a Journal of the Royal College of Radiologists·E A WhiteC N Catton
Sep 18, 2007·International Journal of Radiation Oncology, Biology, Physics·Jasper NijkampJoos V Lebesque
Dec 13, 2006·International Journal of Radiation Oncology, Biology, Physics·Yongbin ZhangLei Dong
Aug 17, 2011·Journal of Medical Imaging and Radiation Oncology·Simon BrownDavid Nicol
Jun 6, 2006·International Journal of Radiation Oncology, Biology, Physics·Matthias GuckenbergerMichael Flentje
Oct 29, 2005·International Journal of Radiation Oncology, Biology, Physics·Monique H P SmitsmansMarcel van Herk
Dec 19, 2013·International Journal of Biomedical Imaging·Zijie XuEdward Chaney
Aug 23, 2007·Journal of Applied Clinical Medical Physics·Chester R RamseyStephen Mahan
Nov 18, 2009·Journal of Applied Clinical Medical Physics·D RyanB Gino Fallone
Nov 21, 2008·Journal of Applied Clinical Medical Physics·Guang LiRobert W Miller
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Sep 26, 2007·International Journal of Radiation Oncology, Biology, Physics·Patrick A KupelianSanford L Meeks
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Mar 14, 2007·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·Laura A Dawson, David A Jaffray
Jan 16, 2007·Zeitschrift für medizinische Physik·David Sarrut

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