Automatic quantification of lobular inflammation and hepatocyte ballooning in nonalcoholic fatty liver disease liver biopsies.

Human Pathology
Scott VanderbeckSamer Gawrieh

Abstract

Automatic quantification of cardinal histologic features of nonalcoholic fatty liver disease (NAFLD) may reduce human variability and allow continuous rather than semiquantitative assessment of injury. We recently developed an automated classifier that can detect and quantify macrosteatosis with greater than or equal to 95% precision and recall (sensitivity). Here, we report our early results on the classifier's performance in detecting lobular inflammation and hepatocellular ballooning. Automatic quantification of lobular inflammation and ballooning was performed on digital images of hematoxylin and eosin-stained slides of liver biopsy samples from 59 individuals with normal liver histology and varying severity of NAFLD. Two expert hepatopathologists scored liver biopsies according the nonalcoholic steatohepatitis clinical research network scoring system and provided annotations of lobular inflammation and hepatocyte ballooning on the digital images. The classifier had precision and recall of 70% and 49% for lobular inflammation, and 91% and 54% for hepatocyte ballooning. In addition, the classifier had an area under the curve of 95% for lobular inflammation and 98% for hepatocyte ballooning. The Spearman rank correlation coef...Continue Reading

References

May 29, 1999·Gastroenterology·C A MatteoniA J McCullough
Jul 29, 2003·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jason M HuiJacob George
Nov 27, 2004·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Jeffrey D BrowningHelen H Hobbs
May 26, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·David E KleinerUNKNOWN Nonalcoholic Steatohepatitis Clinical Research Network
Feb 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arun J SanyalAlan S Mills
Aug 8, 2006·Hepatology Research : the Official Journal of the Japan Society of Hepatology·Toshio FukusatoUNKNOWN Liver Disease Working Group-Kanto
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Mattias EkstedtStergios Kechagias
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Raphael B MerrimanNathan M Bass
Oct 4, 2006·Pediatrics·Jeffrey B SchwimmerCynthia Behling
Mar 3, 2010·Nature Reviews. Gastroenterology & Hepatology·Elizabeth M Brunt
Mar 2, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Zobair M YounossiZachary Goodman
Apr 27, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Arun J SanyalArthur McCullough

❮ Previous
Next ❯

Citations

Feb 12, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Samer GawriehScott Vanderbeck
Mar 13, 2018·World Journal of Hepatology·Marcello ManciniFerruccio Bonino
May 11, 2018·PloS One·Deepak SethunathSamer Gawrieh
Oct 11, 2019·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Feng LiuLai Wei
Feb 12, 2021·Nature Reviews. Gastroenterology & Hepatology·Raj VuppalanchiArun J Sanyal
Mar 13, 2021·Journal of Gastroenterology and Hepatology·Tung-Hung SuJia-Horng Kao
Oct 25, 2020·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Joseph C AhnVijay H Shah
Feb 12, 2021·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Amaro Taylor-WeinerZobair M Younossi
Jul 31, 2021·Seminars in Liver Disease·Karl VazAmmar Majeed

❮ Previous
Next ❯

Related Concepts

Related Feeds

Adrenocortical Carcinoma

Hepatocellular carcinoma is the most common type of primary liver cancer and frequently occurs in individuals with chronic liver diseases like cirrhosis. Here is the latest research.

Carcinoma, Hepatocellular

Hepatocellular Carcinoma is a malignant cancer in liver epithelial cells. Discover the latest research on Hepatocellular Carcinoma here.

Carcinoma, Lobular

Lobular carcinoma is an invasive type of breast cancer in which lobules, areas of the breast that produce milk, undergo malignant transformation. Here is the latest research.