Automatic segmentation of cerebrospinal fluid, white and gray matter in unenhanced computed tomography images

Academic Radiology
Varsha GuptaWieslaw L Nowinski

Abstract

Although segmentation algorithms for cerebrospinal fluid (CSF), white matter (WM), and gray matter (GM) on unenhanced computed tomographic (CT) images exist, there is no complete research in this area. To take into account poor image contrast and intensity variability on CT scans, the aim of this study was to derive and validate a novel, automatic, adaptive, and robust algorithm. Unenhanced CT scans of normal subjects from two different centers were used. The algorithm developed uses adaptive thresholding, connectivity, and domain knowledge and is based on heuristics on the shape of CT histogram. The slope of the intensity histogram corresponding to the three-dimensional largest connected region in a variable CSF intensity range is tracked to determine the critical intensity, which serves as an initial classifier of CSF-WM. Thresholds of CSF, WM, and GM are then optimally derived to minimize classification overlap. Multiple, null, and erroneous classifications are resolved by applying domain knowledge. The ground-truth regions with the minimal partial volume effect were used to evaluate segmentation results using the statistical markers. Average sensitivity, Dice index, and specificity, respectively, for the first center were 9...Continue Reading

References

Jan 1, 1978·Neuroradiology·H Hacker, H Artmann
Feb 1, 1985·Computers and Biomedical Research, an International Journal·J M DeLeoS I Rapoport
Jun 1, 1993·Psychiatry Research·U E RuttimannM J Eckardt
Jun 10, 2008·Human Brain Mapping·Frederick KlauschenArvid Lundervold
Mar 11, 2009·IEEE Transactions on Information Technology in Biomedicine : a Publication of the IEEE Engineering in Medicine and Biology Society·Ujjwal Maulik

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Citations

Sep 26, 2015·Radiological Physics and Technology·Noriyuki TakahashiDu-Yih Tsai
Mar 22, 2012·Anatomical Sciences Education·Pablo RuisotoAlberto Prats-Galino
Jul 1, 2014·The Neuroradiology Journal·Wieslaw L NowinskiDaniel F Hanley
Oct 28, 2016·Journal of Neuroimaging : Official Journal of the American Society of Neuroimaging·Ryszard S GomolkaWieslaw L Nowinski
Aug 9, 2017·Journal of Computer Assisted Tomography·Keith A CauleySamuel W Fielden
Mar 10, 2017·Scientific Reports·Rashindra ManniesingBram van Ginneken
Apr 16, 2020·Neuroinformatics·Wieslaw L Nowinski
Mar 9, 2017·BioMed Research International·Xiaohua QianJing Wang

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