Automatic segmentation of closed-contour features in ophthalmic images using graph theory and dynamic programming.

Biomedical Optics Express
Stephanie J ChiuSina Farsiu

Abstract

This paper presents a generalized framework for segmenting closed-contour anatomical and pathological features using graph theory and dynamic programming (GTDP). More specifically, the GTDP method previously developed for quantifying retinal and corneal layer thicknesses is extended to segment objects such as cells and cysts. The presented technique relies on a transform that maps closed-contour features in the Cartesian domain into lines in the quasi-polar domain. The features of interest are then segmented as layers via GTDP. Application of this method to segment closed-contour features in several ophthalmic image types is shown. Quantitative validation experiments for retinal pigmented epithelium cell segmentation in confocal fluorescence microscopy images attests to the accuracy of the presented technique.

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Citations

Aug 29, 2013·International Journal of Biomedical Imaging·Jan Marek Marcinczak, Rolf-Rainer Grigat
Dec 11, 2013·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Piero Rangel-FonsecaEthan A Rossi
Sep 15, 2015·Journal of the Optical Society of America. A, Optics, Image Science, and Vision·Letizia Mariotti, Nicholas Devaney
Aug 27, 2015·Biomedical Optics Express·Nathan S AlexanderKrzysztof Palczewski
Jan 15, 2015·IEEE Transactions on Image Processing : a Publication of the IEEE Signal Processing Society· Zhi LuAndrew P Bradley
Feb 7, 2015·Biomedical Optics Express·Andrew LangJerry L Prince
Jun 14, 2013·Biomedical Optics Express·Stephanie J ChiuSina Farsiu
Nov 5, 2017·Scientific Reports·Glenn YiuSara M Thomasy
Feb 23, 2020·Investigative Ophthalmology & Visual Science·Glenn YiuSara M Thomasy
Nov 8, 2018·Journal of Ophthalmology·LakshmiPriya RangarajuMahnaz Shahidi
Aug 21, 2020·Translational Vision Science & Technology·Yi-Zhong WangDavid G Birch
Aug 25, 2020·Translational Vision Science & Technology·Qitong GaoMajda Hadziahmetovic
Jul 3, 2013·European Journal of Ophthalmology·Claudio AzzoliniGianni Virgili
Mar 9, 2021·Biomedical Optics Express·Nripun SredarAlfredo Dubra
Aug 3, 2021·Medical Image Analysis·Raidel Herrera-PeredaMárcio Holsbach Costa

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Methods Mentioned

BETA
fluorescence microscopy
confocal microscopy

Software Mentioned

PNAS
MATLAB
AOSO

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