Automatic sorting of multiple unit neuronal signals in the presence of anisotropic and non-Gaussian variability

Journal of Neuroscience Methods
M S FeeDavid Kleinfeld

Abstract

Neuronal noise sources and systematic variability in the shape of a spike limit the ability to sort multiple unit waveforms recorded from nervous tissue into their single neuron constituents. Here we present a procedure to efficiently sort spikes in the presence of noise that is anisotropic, i.e., dominated by particular frequencies, and whose amplitude distribution may be non-Gaussian, such as occurs when spike waveforms are a function of interspike interval. Our algorithm uses a hierarchical clustering scheme. First, multiple unit records are sorted into an overly large number of clusters by recursive bisection. Second, these clusters are progressively aggregated into a minimal set of putative single units based on both similarities of spike shape as well as the statistics of spike arrival times, such as imposed by the refractory period. We apply the algorithm to waveforms recorded with chronically implanted micro-wire stereotrodes from neocortex of behaving rat. Natural extension of the algorithm may be used to cluster spike waveforms from records with many input channels, such as those obtained with tetrodes and multiple site optical techniques.

References

Mar 1, 1992·Journal of Neuroscience Methods·H Bergman, M R DeLong
Mar 1, 1990·Trends in Neurosciences·B W Connors, M J Gutnick
Mar 1, 1986·New Directions for Child Development·B K Keogh
Dec 1, 1984·Journal of Neuroscience Methods·E M Schmidt
Jan 1, 1994·Journal of Neuroscience Methods·M MeisterD A Baylor
Aug 20, 1993·Science·M A Wilson, B L McNaughton

❮ Previous
Next ❯

Citations

Jul 17, 2010·Journal of Computational Neuroscience·Ifije E Ohiorhenuan, Jonathan D Victor
Apr 23, 2004·Journal of Neuroscience Methods·Richard B Stein, Douglas J Weber
Jan 22, 2003·Journal of Neuroscience Methods·Christophe PouzatGilles Laurent
Feb 8, 2003·Journal of Neuroscience Methods·Charles C Horn, Mark I Friedman
Jun 20, 2003·Journal of Neuroscience Methods·A J SpenceM S Isaacson
Aug 9, 2003·Journal of Neuroscience Methods·Shy ShohamRichard A Normann
Jul 17, 1998·Journal of Neuroscience Methods·W L Miller, K A Sigvardt
Nov 20, 1998·Journal of Neuroscience Methods·R K Snider, A B Bonds
Jan 5, 1999·Journal of Neuroscience Methods·P GurziG Biella
Oct 16, 1999·Journal of Neuroscience Methods·K S Guillory, R A Normann
Jul 6, 2010·Nature·Ifije E OhiorhenuanJonathan D Victor
Mar 1, 2012·Nature·Shawn R OlsenMassimo Scanziani
Mar 10, 2009·Nature Neuroscience·John C Curtis, David Kleinfeld
Apr 6, 2004·Nature Neuroscience·Tansu CelikelDaniel E Feldman
Sep 29, 2004·Nature Neuroscience·Ronen SegevMichael J Berry
Feb 6, 2013·Nature Nanotechnology·Micha E Spira, Aviad Hai
Feb 13, 1999·The European Journal of Neuroscience·A CzurkóG Buzsáki
Nov 13, 2009·Proceedings of the National Academy of Sciences of the United States of America·Bijan Pesaran, David Kleinfeld
Mar 6, 2003·Network : Computation in Neural Systems·David P NguyenEmery N Brown
Aug 12, 2009·Journal of Neural Engineering·Ariel TankusItzhak Fried
Mar 28, 2006·IEEE Transactions on Neural Systems and Rehabilitation Engineering : a Publication of the IEEE Engineering in Medicine and Biology Society·Xindong LiuWilliam F Agnew
Apr 13, 2012·Journal of Neurophysiology·Eran StarkGyörgy Buzsáki
Sep 9, 2005·Journal of Neurophysiology·Jonathan D VictorTatyana Sharpee
Sep 16, 2005·Journal of Neurophysiology·Elisabeth FoellerDaniel E Feldman
Apr 2, 2010·Journal of Neurophysiology·Sheila NirenbergJonathan D Victor
Apr 20, 2012·Journal of Neurophysiology·Lucas HerfstMichael Brecht
Jul 30, 2011·PloS One·Jason S PrenticePhilip C Nelson
Mar 4, 2014·PloS One·Ifije E OhiorhenuanJonathan D Victor
Apr 15, 2014·PloS One·Palmi Thor ThorbergssonAnders J Johansson
Jun 17, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Daniel N HillDavid Kleinfeld
Sep 13, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Zachary NicholsJonathan Victor
Apr 8, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shreesh P MysoreEric I Knudsen
May 27, 2011·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Shreesh P Mysore, Eric I Knudsen
Aug 8, 2014·Computational Intelligence and Neuroscience·Vincent Vigneron, Hsin Chen
Dec 18, 2013·Journal of Neuroscience Methods·Vahid Shalchyan, Dario Farina
Oct 17, 2015·Biosensors·Nicolas A AlbaX Tracy Cui
Mar 6, 2012·Journal of Neuroscience Methods·Douglas M SchwarzLaurel H Carney
Nov 1, 2011·Journal of Neuroscience Methods·Jiri WildRobert Jech
Nov 8, 2011·Journal of Physiology, Paris·Hongying GaoClément Lena

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.