Abstract
White matter (WM) lesions are diffuse WM abnormalities that appear as hyperintense (bright) regions in cranial magnetic resonance imaging (MRI). WM lesions are often observed in older populations and are important indicators of stroke, multiple sclerosis, dementia and other brain-related disorders. In this paper, a new automated method for WM lesions segmentation is presented. In the proposed method, the presence of WM lesions is detected as outliers in the intensity distribution of the fluid-attenuated inversion recovery (FLAIR) MR images using an adaptive outlier detection approach. Outliers are detected using a novel adaptive trimmed mean algorithm and box-whisker plot. In addition, pre- and postprocessing steps are implemented to reduce false positives attributed to MRI artifacts commonly observed in FLAIR sequences. The approach is validated using the cranial MRI sequences of 38 subjects. A significant correlation (R=0.9641, P value=3.12×10(-3)) is observed between the automated approach and manual segmentation by radiologist. The accuracy of the proposed approach was further validated by comparing the lesion volumes computed using the automated approach and lesions manually segmented by an expert radiologist. Finally, the...Continue Reading
References
Nov 18, 1977·Science·J W Tukey
Nov 1, 1992·Journal of Magnetic Resonance Imaging : JMRI·R KikinisH Cline
Nov 22, 1997·IEEE Transactions on Medical Imaging·J K UdupaR I Grossman
Jun 9, 1998·IEEE Transactions on Medical Imaging·J G SledA C Evans
Sep 8, 2000·Stroke; a Journal of Cerebral Circulation·N HironoE Mori
Jun 2, 2001·Stroke; a Journal of Cerebral Circulation·L O WahlundUNKNOWN European Task Force on Age-Related White Matter Changes
Dec 18, 2001·Journal of Magnetic Resonance Imaging : JMRI·C R JackB J Erickson
Apr 24, 2002·Journal of Neurology, Neurosurgery, and Psychiatry·H YamauchiC Oyanagi
Aug 8, 2002·Psychiatry Research·Martha E PayneK Ranga R Krishnan
Oct 23, 2002·Human Brain Mapping·Stephen M Smith
Mar 10, 2004·NeuroImage·Petronella AnbeekJeroen van der Grond
Apr 28, 2004·NeuroImage·Wei Wen, Perminder Sachdev
Oct 27, 2004·NeuroImage·Stephen M SmithPaul M Matthews
Jul 26, 2005·Topics in Magnetic Resonance Imaging : TMRI·Lenore J Launer
Sep 1, 2005·NeuroImage·F Admiraal-BehloulJ H C Reiber
May 16, 2006·NeuroImage·Audrey H ZhuangArthur W Toga
Nov 14, 2006·Psychiatry Research·Minjie WuHoward J Aizenstein
Jan 31, 2008·Practical Neurology·Mike O'Sullivan
Apr 29, 2008·Medical Image Analysis·S BricqJ P Armspach
Jul 9, 2008·Neurology·L C SilbertJ A Kaye
Dec 25, 2008·Annals of Neurology·Simone AppenzellerFernando Cendes
Apr 7, 2009·NeuroImage·Renske de BoerWiro J Niessen
Apr 7, 2009·NeuroImage·Richard BeareDavid Reutens
Sep 22, 2009·NeuroImage·Navid ShieeDzung L Pham
Jul 28, 2010·BMJ : British Medical Journal·Stéphanie Debette, H S Markus
Citations
May 15, 2013·Journal of Neurosurgery. Pediatrics·David S HershSarah S Milla
May 6, 2014·NeuroImage·Jhimli MitraLeeanne Carey
May 21, 2013·Magnetic Resonance Imaging·Rita SimõesCornelis Slump
Apr 8, 2015·IEEE Transactions on Medical Imaging·Carole H SudreSebastien Ourselin
Feb 5, 2015·Neuroinformatics·Maria Eugenia CaligiuriAndrea Cherubini
Aug 19, 2014·Magnetic Resonance Imaging·Rui WangSu Zhang
Nov 20, 2014·Neuroradiology·Rui WangSu Zhang
Jun 27, 2013·PloS One·Ahmad BijarAntonio Peñalver Benavent
Jul 13, 2016·NeuroImage·Ludovica GriffantiMark Jenkinson
Nov 1, 2015·BMC Medical Imaging·Dazhou GuoSong Wang
Apr 6, 2017·Neuroinformatics·M RincónA Bjørnerud
Jun 13, 2017·NeuroImage·Mahsa DadarUNKNOWN Alzheimer's Disease Neuroimaging Initiative
Apr 5, 2014·Stroke; a Journal of Cerebral Circulation·Yogheswaran GopalanKah Hay Yuen
Feb 11, 2014·Human Brain Mapping·Vamsi IthapuSterling C Johnson
Jan 25, 2021·Brain and Behavior·Francisco Carlos Pérez-MirallesBonaventura Casanova
Jan 31, 2021·BMJ Open·Emilia GryskaRolf A Heckemann
Jun 4, 2021·Scientific Reports·Subhranil KoleyIman Aganj
Jul 30, 2021·Medical Image Analysis·Vaanathi SundaresanLudovica Griffanti