Autonomic and antiarrhythmic drug modulation of ST segment elevation in patients with Brugada syndrome

Journal of the American College of Cardiology
T MiyazakiS Ogawa

Abstract

We examined the modulatory effects of autonomic nervous system and antiarrhythmic drugs on the ST segment in patients with Brugada syndrome to gain an insight into the mechanism of ST segment elevation. Right bundle branch block, ST segment elevation and ventricular tachyarrhythmias define a distinct clinical and electrocardiographic (ECG) syndrome (Brugada syndrome). However, the mechanism of ST segment elevation and the causes of this syndrome are unknown. The study included four patients in whom structural heart or coronary artery disease was excluded by noninvasive and invasive tests. High take-off ST segment elevation of either the coved or saddle-back type in precordial leads V1, V2 and V3 was seen in all patients. Three patients experienced recurrent episodes of syncope or aborted sudden cardiac death, and the remaining patient had palpitation. Autonomic receptor stimulation and blockade and intravenous administration of antiarrhythmic drugs were performed during sinus rhythm while the 12-lead ECG was recorded. Metaiodobenzylguanidine (MIBG) scanning and Holter monitoring were also performed. Beta-adrenoceptor stimulation by intravenous isoproterenol consistently reduced (> or = 0.1 mV) ST segment elevation at or 80 ms a...Continue Reading

References

Apr 1, 1990·Journal of Hypertension·P D Drummond
Sep 1, 1990·American Heart Journal·S Viskin, B Belhassen
Dec 1, 1989·American Heart Journal·B MartiniS Dalla Volta
Nov 1, 1988·The Journal of Physiology·W R Giles, Y Imaizumi
Nov 1, 1988·Proceedings of the National Academy of Sciences of the United States of America·M Apkon, J M Nerbonne
Mar 15, 1989·Journal of the American College of Cardiology·R LemeryH J Wellens

❮ Previous
Next ❯

Citations

Apr 9, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Mihoko InamuraSumio Hoka
Jul 29, 2005·Zeitschrift für Kardiologie·K KattenbeckH J Odenthal
Dec 20, 2005·Herzschrittmachertherapie & Elektrophysiologie·M PaulT Wichter
Aug 1, 2007·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Arthur A M Wilde, Wouter Wieling
Aug 10, 2002·Current Cardiology Reports·T Scott Wall, Roger A Freedman
Aug 22, 2008·Current Cardiology Reports·Charles Antzelevitch, Eyal Nof
Jun 24, 2011·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Benjamin KloeselToby N Weingarten
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Christian WolpertMartin Borggrefe
Apr 27, 2005·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Stanley Nattel
Jun 28, 2005·Progress in Biophysics and Molecular Biology·Andrew F JamesJules C Hancox
Jan 24, 2006·The Veterinary Journal·Changbaig Hyun, Lucio J Filippich
May 27, 2003·American Heart Journal·Laszlo LittmannJohn J Gallagher
Nov 21, 2000·The American Journal of Cardiology·P BrugadaJ Brugada
Aug 4, 1998·International Journal of Cardiology·M NakamuraH Imamura
Aug 31, 2001·Journal of the American College of Cardiology·Y MiyasakaT Iwasaka
Jun 27, 2002·Journal of the American College of Cardiology·Charles Antzelevitch
Jul 11, 2002·Journal of the American College of Cardiology·Takashi KuritaYoshio Kosakai
Jul 11, 2003·Archives des maladies du coeur et des vaisseaux·A LeenhardtB Cauchemez
Feb 6, 1999·Journal of the American College of Cardiology·I GussakB R Chaitman
Aug 27, 2005·Nature Clinical Practice. Cardiovascular Medicine·Wataru ShimizuShiro Kamakura
Apr 12, 2003·Pacing and Clinical Electrophysiology : PACE·Akihiko NogamiKazutaka Aonuma
Aug 14, 2003·Pacing and Clinical Electrophysiology : PACE·Charles Antzelevitch
Oct 24, 2002·British Journal of Anaesthesia·C J EdgeM Sainsbury
Apr 14, 2012·British Journal of Anaesthesia·C StaikouA Mani
May 31, 2012·European Heart Journal·M Juhani JunttilaRobert J Myerburg
Nov 5, 2013·European Heart Journal·Pedro BrugadaDenis Roy
Dec 20, 2007·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Mohamad Ali Babaee BigiArsalan Aslani
May 10, 2008·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Thomas Wichter
Jan 10, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Vincent ProbstHervé Le Marec
Feb 6, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Carla GiustettoUNKNOWN Italian Association of Arrhythmology and Cardiostimulation (AIAC)-Piedmont Section
Apr 7, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Konstantinos KyriazisKarl-Heinz Kuck
Jun 2, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Yee Guan YapA John Camm
Jul 11, 2009·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Christian VeltmannVincent Probst
Dec 23, 2003·Current Opinion in Cardiology·Richard L Verrier, Charles Antzelevitch
Jul 29, 2009·American Journal of Therapeutics·Chandrasekar PalaniswamyRasham Sandhu

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiology Journals

Discover the latest cardiology research in this collection of the top cardiology journals.

Anti-Arrhythmic Drug Therapies

Anti-arrhythmic drugs are used to prevent abnormal heart rhythms. These medications are used in conditions including, ventricular tachycardia, ventricular fibrillation and atrial fibrillation. Discover the latest research on anti-arrhythmic drug therapies here.

Antiarrhythmic Agents: Mechanisms of Action

Understanding the mechanism of action of antiarrhythmic agents is essential in developing new medications as treatment of cardiac arrhythmias is currently limited by the reduced availability of safe and effective drugs. Discover the latest research on Antiarrhythmic Agents: Mechanism of Action here.

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.

Cardiomyopathy

Cardiomyopathy is a disease of the heart muscle, that can lead to muscular or electrical dysfunction of the heart. It is often an irreversible disease that is associated with a poor prognosis. There are different causes and classifications of cardiomyopathies. Here are the latest discoveries pertaining to this disease.

Arrhythmia

Arrhythmias are abnormalities in heart rhythms, which can be either too fast or too slow. They can result from abnormalities of the initiation of an impulse or impulse conduction or a combination of both. Here is the latest research on arrhythmias.