Autonomic and behavioral thermoregulation in golden hamsters exposed perinatally to dioxin

Toxicology and Applied Pharmacology
Christopher J GordonL E Gray

Abstract

Perinatal exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) cause s a permanent change in thermoregulatory control of male offspring of the rat, characterized by a reduced core temperature (Tc over a wide range of ambient temperatures (Ta). To examine the similarities in this effect across species, the thermoregulatory effects of perinatal TCDD were evaluated in the golden hamster, a species which is very resistant to the lethal effects of TCDD. Adult male hamsters exposed on Gestational Day 11.5-11.75 to 2.0 microgram TCDD/kg by gavage were subjected to a variety of behavioral and autonomic thermoregulatory measurements. Nocturnal Tc of TCDD-treated animals was 0.4 to 1.0 degrees C below that of controls over a Ta range of 14 to 34 degrees C. Hypothermia persisted in spite of normal metabolic responses to cold exposure. The hypothermic effect of perinatal TCDD exposure was found to persist over a 24-hr period in unrestrained hamsters monitored by radiotelemetry. The TCDD-treated hamster offspring placed in a temperature gradient exhibited a preference for warm Ta's for 2 to 3 hr; however, when maintained over a 22-hr period in the gradient there was no effect of TCDD on behavioral thermoregulation. TCDD had no effect on m...Continue Reading

Citations

Jul 27, 2000·Food Additives and Contaminants·L S Birnbaum, J Tuomisto
Jan 10, 2002·Environmental Health Perspectives·Linda S Birnbaum, Audrey M Cummings
May 13, 2006·Endocrinology·Sandra L PetersenEdward D Hudgens
Nov 10, 2020·General and Comparative Endocrinology·Lisa N Bottalico, Aalim M Weljie

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