Autonomic and cardiovascular responses to chemoreflex stress in apnoea divers

Autonomic Neuroscience : Basic & Clinical
Craig D SteinbackJ K Shoemaker

Abstract

Sleep apnoea, with repeated periods of hypoxia, results in cardiovascular morbidity and concomitant autonomic dysregulation. Trained apnoea divers also perform prolonged apnoeas accompanied by large lung volumes, large reductions in cardiac output and severe hypoxia and hypercapnia. We tested the hypothesis that apnoea training would be associated with decreased cardiovagal and sympathetic baroreflex gains and reduced respiratory modulation of muscle sympathetic nerve activity (MSNA; microneurography). Six trained divers and six controls were studied at rest and during asphyxic rebreathing. Despite an elevated resting heart rate (70+/-14 vs. 56+/-10 bpm; p=0.038), divers had a similar cardiovagal baroreflex gain (-1.22+/-0.47 beats/mmHg) as controls (-1.29+/-0.61; NS). Similarly, though MSNA burst frequency was slightly higher in divers at rest (16+/-4 bursts/min vs. 10+/-5 bursts/min, p=0.03) there was no difference in baseline burst incidence, sympathetic baroreflex gain (-3.8+/-2.1%/mmHg vs. -4.7+/-1.7%/mmHg) or respiratory modulation of MSNA between groups. Resting total peripheral resistance (11.9+/-2.6 vs. 12.3+/-2.2 mmHg/L/min) and pulse wave velocity (5.82+/-0.55 vs. 6.10+/-0.51 m/s) also were similar between divers and...Continue Reading

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Citations

Aug 7, 2014·Current Hypertension Reports·Meghna P MansukhaniVirend K Somers
Jun 7, 2011·Autonomic Neuroscience : Basic & Clinical·Toni BreskovicZeljko Dujic
Dec 2, 2017·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Anthony R BainDamian M Bailey
Mar 8, 2018·Experimental Physiology·Anthony R BainPhilip N Ainslie
May 10, 2019·Journal of Applied Physiology·M Erin MoirJ Kevin Shoemaker
May 12, 2012·Sports Medicine·Zeljko Dujic, Toni Breskovic
Sep 10, 2010·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Craig D SteinbackJ Kevin Shoemaker
Jan 30, 2019·Physiological Reports·Stephen A BuschCraig D Steinback
Apr 9, 2020·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Elizabeth P OttJacqueline K Limberg
Mar 20, 2020·International Journal for Numerical Methods in Biomedical Engineering·Luciano G FernandesPablo J Blanco
Jan 12, 2021·Physiological Reports·Stephen A BuschCraig D Steinback
Apr 2, 2021·European Journal of Applied Physiology·Antonis EliaMatthew J Lees

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