Autonomic and cellular mechanisms mediating detrimental cardiac effects of status epilepticus.

Epilepsy Research
Steven L BealerAnne E Anderson

Abstract

Prolonged seizure activity (status epilepticus; SE) can result in increased susceptibility to lethal ventricular arrhythmias for an extended period of time following seizure termination. SE is accompanied by acute, intense activation of the sympathetic nervous system (SymNS) and results in myocyte myofilament damage, arrhythmogenic alterations in cardiac electrical activity, and increased susceptibility to ventricular arrhythmias. However, the mechanisms mediating the changes in cardiac function, and the specific arrhythmogenic substrate produced during SE are unknown. To determine if detrimental cardiac effects of SE are mediated by SymNS stimulation of the heart, we examined the effects of B-adrenergic blockade (atenolol) during seizure activity on blood pressure, heart rate, myocyte myofilament injury (cardiac troponin I, cTnI), electrocardiographic activity, and susceptibility to arrhythmias. Furthermore, we determined if SE was associated with altered expression of the Kv4.x potassium channels, which are critical for action potential repolarization and thereby contribute significantly to normal cardiac electrical activity. Lithium-pilocarpine induced SE was associated with acute tachycardia, hypertension, and cardiomyocyte...Continue Reading

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Citations

Oct 22, 2013·Bulletin of Experimental Biology and Medicine·M L Mamalyga
Dec 17, 2011·Science Translational Medicine·Mark D McCauleyJeffrey L Neul
Jul 19, 2014·Journal of the Neurological Sciences·Josef Finsterer, Karim Wahbi
Sep 17, 2013·Archives of Medical Research·Masoud MehrpourPoorang Bassir
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May 15, 2015·Epilepsy & Behavior : E&B·Sara Hocker
Oct 13, 2017·The Journal of Small Animal Practice·E DuttonA Boswood
Aug 2, 2019·CNS & Neurological Disorders Drug Targets·Supriya SharmaDamanpreet Singh
Sep 6, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Morgayn I ReadIvan A Sammut
Sep 23, 2020·Annals of the New York Academy of Sciences·Laxmikant S DeshpandeRobert J DeLorenzo
Mar 7, 2020·Scientific Reports·Amber T LevineAnne E Anderson
Jun 16, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M L Mamalyga, L M Mamalyga

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