Abstract
Prolonged seizure activity (status epilepticus; SE) can result in increased susceptibility to lethal ventricular arrhythmias for an extended period of time following seizure termination. SE is accompanied by acute, intense activation of the sympathetic nervous system (SymNS) and results in myocyte myofilament damage, arrhythmogenic alterations in cardiac electrical activity, and increased susceptibility to ventricular arrhythmias. However, the mechanisms mediating the changes in cardiac function, and the specific arrhythmogenic substrate produced during SE are unknown. To determine if detrimental cardiac effects of SE are mediated by SymNS stimulation of the heart, we examined the effects of B-adrenergic blockade (atenolol) during seizure activity on blood pressure, heart rate, myocyte myofilament injury (cardiac troponin I, cTnI), electrocardiographic activity, and susceptibility to arrhythmias. Furthermore, we determined if SE was associated with altered expression of the Kv4.x potassium channels, which are critical for action potential repolarization and thereby contribute significantly to normal cardiac electrical activity. Lithium-pilocarpine induced SE was associated with acute tachycardia, hypertension, and cardiomyocyte...Continue Reading
References
Jan 1, 1992·Epilepsia·R J DeLorenzoD Ko
Sep 1, 1990·Epilepsia·J H GoodmanI L Crawford
May 1, 1987·Toxicology Letters·A W SingerC G McLeod
Jun 1, 1995·Circulation Research·W D GaoE Marban
Jan 1, 1994·Epilepsia·A R TowneR J DeLorenzo
Jan 1, 1993·Epilepsy Research·J G BoggsR J DeLorenzo
Apr 6, 1996·BMJ : British Medical Journal·D DarbarA D Struthers
Oct 24, 1997·Annals of Neurology·S C JohnstonK D Laxer
Apr 2, 1998·The New England Journal of Medicine·D H Lowenstein, B K Alldredge
Aug 29, 1998·Epilepsy Research·J G BoggsR J DeLorenzo
Mar 29, 2000·Japanese Heart Journal·K SatoT Izumi
Feb 7, 2001·The Journal of Physiology·T VolkH Ehmke
Jul 21, 2001·Epilepsy Research·M GlienW Löscher
Jul 27, 2001·Fundamental & Clinical Pharmacology·Y Ishiguro, J P Morgan
Dec 19, 2001·Circulation·R A Kloner, R B Jennings
Jun 28, 2002·The New England Journal of Medicine·Elliott M Antman
Sep 10, 2002·The Journal of Emergency Medicine·John Sarko, Charles V Pollack
Jan 13, 2004·American Journal of Physiology. Heart and Circulatory Physiology·Angela J GrippoAlan Kim Johnson
Jan 6, 2006·Epilepsia·Giancarlo LogroscinoPierre Jallon
Apr 8, 2006·Laboratory Animals·P J O'BrienW J Reagan
Oct 25, 2006·Circulation·Matteo VattaJeffrey A Towbin
Nov 18, 2006·The Journal of Physiology·Barry LondonGuy Salama
Feb 8, 2007·Experimental Animals·Masaaki KurataNorimitsu Shirai
Mar 8, 2008·Epilepsia·Kenichi SakamotoMark Stewart
Apr 19, 2008·Anesthesia and Analgesia·Taketo NakamuraAkira Asada
May 29, 2008·Neurocritical Care·Stephane LegrielJean Pierre Bedos
Jul 2, 2008·Proceedings of the National Academy of Sciences of the United States of America·Kazuo UedaJonathan C Makielski
Oct 22, 2008·Neuroscience·T SuW P Liao
Jan 28, 2009·Circulation·Sumeet S ChughJonathan Jui
May 21, 2009·Epilepsia·L Forbes S BarnwellAnne E Anderson
Jul 4, 2009·Herz·Rainer SchimpfMartin Borggrefe
Aug 18, 2009·Circulation. Arrhythmia and Electrophysiology·Geru WuMatteo Vatta
Citations
Oct 22, 2013·Bulletin of Experimental Biology and Medicine·M L Mamalyga
Dec 17, 2011·Science Translational Medicine·Mark D McCauleyJeffrey L Neul
Mar 24, 2012·PloS One·Ching-Yi TsaiSamuel H H Chan
Jul 19, 2014·Journal of the Neurological Sciences·Josef Finsterer, Karim Wahbi
Sep 17, 2013·Archives of Medical Research·Masoud MehrpourPoorang Bassir
Mar 8, 2013·Seminars in Pediatric Neurology·Sumit Parikh, Ajay Gupta
Jun 12, 2012·Annales Françaises D'anesthèsie Et De Rèanimation·P-M MertesG Audibert
Jan 3, 2012·Epilepsy Research·Jason G Little, Steven L Bealer
May 15, 2015·Epilepsy & Behavior : E&B·Sara Hocker
Mar 15, 2015·British Journal of Pharmacology·M I ReadI A Sammut
Jan 29, 2013·Epilepsy Research·Steven L Bealer, Jason G Little
Aug 25, 2016·Epilepsia·Amy L BrewsterYi-Chen Lai
Oct 13, 2017·The Journal of Small Animal Practice·E DuttonA Boswood
Mar 8, 2018·Epilepsia·Morgayn I ReadIvan A Sammut
Apr 27, 2018·Epilepsia·Guilherme L FialhoKatia Lin
Jul 30, 2019·Epilepsia·Michael C H LiKim L Powell
Aug 2, 2019·CNS & Neurological Disorders Drug Targets·Supriya SharmaDamanpreet Singh
Jun 13, 2020·Diagnostics·Enes AkyuzChiara Villa
Sep 6, 2015·American Journal of Physiology. Heart and Circulatory Physiology·Morgayn I ReadIvan A Sammut
Sep 23, 2020·Annals of the New York Academy of Sciences·Laxmikant S DeshpandeRobert J DeLorenzo
Mar 7, 2020·Scientific Reports·Amber T LevineAnne E Anderson
Jun 9, 2018·Epilepsia Open·Yi-Chen LaiAnne E Anderson
Jun 16, 2017·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·M L Mamalyga, L M Mamalyga
Feb 26, 2015·Disease Models & Mechanisms·José A HerreraJeffrey L Neul
Jun 19, 2021·Epilepsy & Behavior : E&B·Guilherme L FialhoKatia Lin