Autonomic changes in psychogenic nonepileptic seizures: toward a potential diagnostic biomarker?

Clinical EEG and Neuroscience
Claus ReinsbergerBarbara A Dworetzky

Abstract

Disturbances of the autonomic nervous system (ANS) are common in neuropsychiatric disorders. Disease specific alterations of both sympathetic and parasympathetic activity can be assessed by heart rate variability (HRV), whereas electrodermal activity (EDA) can assess sympathetic activity. In posttraumatic stress disorder (PTSD), parasympathetic HRV parameters are typically decreased and EDA is increased, whereas in major depressive disorder (MDD) and dissociation, both parasympathetic and sympathetic markers are decreased. ANS abnormalities have also been identified in psychogenic nonepileptic seizures (PNES) by using HRV, indicating lower parasympathetic activity at baseline. In addition to reviewing the current literature on ANS abnormalities in PTSD, MDD, and disorders with prominent dissociation, including borderline personality disorder (BPD), this article also presents data from a pilot study on EDA in patients with PNES. Eleven patients with PNES, during an admission to our epilepsy monitoring unit (EMU), were compared with 9 with generalized tonic-clonic seizures (GTCS). The area under the EDA curve, the number of EDA responses lasting longer than 2 seconds, and the number of EDA surges during sleep (sympathetic sleep s...Continue Reading

References

May 1, 1991·Acta Psychiatrica Scandinavica·F KellerG Hole
Jan 1, 1988·Experimental Brain Research·S G Hardy, D E Holmes
Aug 1, 1988·Acta Psychiatrica Scandinavica·L H Thorell, G d'Elia
Dec 1, 1987·Acta Psychiatrica Scandinavica·L H ThorellG d'Elia
Feb 1, 1985·Biological Psychiatry·K M WilliamsR A Remick
Jun 1, 1965·Brain : a Journal of Neurology·N Geschwind
Dec 1, 1983·Psychiatry Research·N G WardM C Storrie
May 1, 1981·Psychophysiology·D C FowlesP H Venables
Jan 1, 1995·Neuroscience and Biobehavioral Reviews·S W Porges
Dec 1, 1994·Yonsei Medical Journal·J H YoonB K Cho
Apr 1, 1994·Acta Psychiatrica Scandinavica·M Wolfersdorf, R Straub
Dec 1, 1995·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·R A BryantR J Barry
Apr 1, 1996·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·C A Mangina, J H Beuzeron-Mangina
Aug 1, 1997·The American Journal of Psychiatry·M G GriffinM B Mechanic
Mar 3, 1998·Progress in Neurobiology·A J Verberne, N C Owens
Nov 10, 1998·Biological Psychiatry·M Sierra, G E Berrios
Oct 13, 1999·The American Journal of Psychiatry·S C HerpertzH Sass
Feb 28, 2002·Neurology·Christian Opherk, Lawrence J Hirsch
Jul 9, 2004·Journal of the Neurological Sciences·Matthias DütschMax Josef Hilz
Jul 12, 2005·Psychoneuroendocrinology·Julian F Thayer, Jos F Brosschot
Aug 24, 1934·The Journal of Physiology·H H Dale, W Feldberg
Sep 30, 2006·Biological Psychiatry·A A T Simone ReindersJohan A den Boer
Oct 19, 2006·Biological Psychology·Jonathan Rottenberg
Oct 20, 2006·Biological Psychology·Stephen W Porges
Oct 28, 2006·Biological Psychology·John W DenverStephen W Porges
Jan 5, 2007·Psychological Medicine·Ulrich W Ebner-PriemerMartin Bohus
Nov 10, 2007·Psychosomatic Medicine·Jens BlechertFrank H Wilhelm
Dec 7, 2007·The American Journal of Psychiatry·David SilbersweigEmily Stern
Sep 16, 2009·Brain and Cognition·Anna WeinbergGreg Hajcak
Oct 20, 2009·Arquivos de neuro-psiquiatria·Gisele R de OliveiraFrancisco H Rola
Jan 14, 2010·Epilepsia·Cristian Sevcencu, Johannes J Struijk
Feb 4, 2010·Neurology·Rainer SurgesMatthew C Walker
Feb 23, 2010·IEEE Transactions on Bio-medical Engineering·Ming-Zher PohRosalind W Picard
Apr 3, 2010·The American Journal of Psychiatry·Ruth A LaniusDavid Spiegel
Dec 15, 2010·Brain and Cognition·Petr Bob, Miroslav Svetlak
Nov 22, 2011·Epilepsy & Behavior : E&B·Claus ReinsbergerBarbara A Dworetzky

❮ Previous
Next ❯

Citations

Feb 28, 2016·Seizure : the Journal of the British Epilepsy Association·Jesper JeppesenAnders Fuglsang-Frederiksen
Jan 18, 2016·Seizure : the Journal of the British Epilepsy Association·T SundararajanX F Jimenez
Apr 17, 2016·Clinical Psychology Review·Richard J Brown, Markus Reuber
Mar 22, 2016·CNS Spectrums·David L Perez, W Curt LaFrance
Apr 15, 2020·Harvard Review of Psychiatry·Michael HsuJoji Suzuki
Nov 17, 2020·Frontiers in Integrative Neuroscience·Elliot HedmanRosalind Picard
Oct 24, 2020·Clinical and Experimental Pediatrics·Jung Sook YeomSookyong Koh
Sep 6, 2021·Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova·G V KustovA B Guekht
Aug 17, 2020·Seizure : the Journal of the British Epilepsy Association·Hugo HerreroCoraline Hingray
Oct 30, 2021·The Journal of Neuropsychiatry and Clinical Neurosciences·Sara Paredes-EcheverriDavid L Perez

❮ Previous
Next ❯

Methods Mentioned

BETA
RSA
biosensors

Clinical Trials Mentioned

NCT01325623

Related Concepts

Related Feeds

Anxiety Disorders

Discover the latest research on anxiety disorders including agoraphobia, panic disorder, obsessive-compulsive disorder, and post-traumatic stress disorder here.