Autonomic dysfunction independently predicts poor cardiovascular outcomes in asymptomatic individuals with type 2 diabetes in the DIAD study

SAGE Open Medicine
Deborah A ChyunDIAD Investigators

Abstract

The primary aim of this secondary analysis was to determine whether cardiac autonomic neuropathy independently predicted adverse cardiac outcomes in asymptomatic individuals with type 2 diabetes. Additional aims include the determination of the correlation of standard autonomic testing measures and power spectral analysis of heart rate variability, and the association of diabetes-related and cardiac risk factors with cardiac autonomic neuropathy measures. Cardiac autonomic neuropathy was assessed at the study entry into the Detection of Ischemia in Asymptomatic Diabetics study, using autonomic heart rate and blood pressure testing, and power spectral analysis of heart rate variability. All participants were prospectively followed for the composite clinical outcome of cardiac death, acute coronary syndromes, heart failure, or coronary revascularization. Over 5 years of follow-up, 94 of 1119 (8.4%) subjects developed symptomatic cardiac disease. In unadjusted bivariate analyses, abnormalities in several cardiac autonomic neuropathy tests, including lower Valsalva and Standing Heart Rate Ratios, higher resting Heart Rate, greater systolic blood pressure decrease on standing, and lower low-frequency power, were predictive of sympto...Continue Reading

References

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Citations

Nov 18, 2016·The International Journal of Cardiovascular Imaging·Vladan VukomanovicVera Celic
Sep 9, 2017·The Physician and Sportsmedicine·Ljiljana BjelakovicBojko Bjelakovic
Dec 7, 2018·Current Opinion in Endocrinology, Diabetes, and Obesity·Rachel WhootenTakara Stanley
Aug 31, 2018·Acta Diabetologica·Federico BellavereGiuseppe Bax

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Software Mentioned

Statistical Analysis System ( SAS ) INSIGHT
Anscore
Marquette HRV Tool

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