Autonomic dysfunction predicts both 1- and 2-month mortality in middle-aged patients with multiple organ dysfunction syndrome

Critical Care Medicine
Hendrik SchmidtKarl Werdan

Abstract

Multiple organ dysfunction syndrome (MODS) is a disease entity that carries a high mortality rate. It is characterized by a sequential failure of several organ systems after a trigger event, most commonly sepsis. There is increasing evidence that autonomic dysfunction may substantially contribute to the development of MODS. We recently characterized the spectrum of autonomic dysfunction by using heart rate variability in critically ill MODS patients and were able to show that autonomic dysfunction predicts 28-day mortality in MODS. The aim of the present study was evaluate whether autonomic dysfunction is also a predictor of 180-day and 365-day mortalities. Prospective cohort study. Twelve-bed medical intensive care unit in a university center. Ninety consecutively admitted score-defined MODS patients. We assessed heart rate variability as a marker of autonomic dysfunction. The patients were followed for 180- and 365-day mortalities. We prospectively used the heart rate variability variable lnVLF, which predicted 28-day mortality best in the entire cohort of patients, for analysis of longer term mortality. The variable lnVLF was found to be useful for risk prediction for about 60 days, and then the survival curves became nearly...Continue Reading

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Citations

Nov 4, 2011·Clinical Research in Cardiology : Official Journal of the German Cardiac Society·Robert S HokeHenning Ebelt
Apr 24, 2008·Critical Care Medicine·Phyllis K Stein
Jun 4, 2008·Critical Care Medicine·Hendrik SchmidtKarl Werdan
Feb 16, 2013·Current Opinion in Pulmonary Medicine·Mervyn Singer
Jan 25, 2014·Critical Care : the Official Journal of the Critical Care Forum·Chun-Ta HuangChong-Jen Yu
May 14, 2014·Digestive Diseases and Sciences·Luyao ZhangJieshou Li
Mar 25, 2014·Heart Failure Clinics·Claudio Ronco, Luca Di Lullo
Jan 19, 2016·Journal of Critical Care·Chenxi HuangIsmail Gögenur
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Mar 18, 2016·Critical Care : the Official Journal of the Critical Care Forum·Hubertus AxerOtto W Witte
Mar 4, 2014·Journal of Molecular and Cellular Cardiology·Susanne ScheruebelBrigitte Pelzmann
May 26, 2011·Journal of Molecular and Cellular Cardiology·Udo KlöcknerMichael Gekle
Aug 21, 2016·British Journal of Anaesthesia·A TonerUNKNOWN POM-O Study Investigators
Apr 17, 2009·Canadian Journal of Physiology and Pharmacology·Karl WerdanUrsula Müller-Werdan
Mar 20, 2013·Korean Circulation Journal·Doo Sun SimUNKNOWN Other Korea Acute Myocardial Infarction Registry (KAMIR) Investigators
Jan 10, 2012·Current Opinion in Critical Care·Onnen Moerer
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Mar 20, 2013·Critical Care Medicine·Gareth L AcklandAlexander V Gourine
Jun 4, 2020·Journal of the Intensive Care Society·Brian W JohnstonIngeborg D Welters

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