Autonomic evaluation by means of standard tests and power spectral analysis in multiple sclerosis

Muscle & Nerve
D LindenP Berlit

Abstract

Standard autonomic tests [heart rate response to deep breathing (HRDB), change in systolic blood pressure due to tilt], and spectral analysis of heart rate (HR), arterial blood pressure (ABP), and the associated transfer function analysis (gains and phases) were performed in 20 patients with multiple sclerosis to determine their diagnostic value. Transfer function analysis suggested impairment of baroreflex function in 7 patients and an alteration of cardiorespiratory coupling on a brain stem level in 4 patients. In addition, sympathetic vasomotor outflow was reduced in 2 patients (spectral ABP measures in the mid frequency band) and a decrease of vagal outflow was suggested by abnormal respiratory HR parameters in another 2 patients. An abnormal HRDB was present in 5 patients and was probably due to a central alteration (cardiorespiratory coupling) in 2 patients and due to diminished respiratory effort in 1 patient. Spectral analysis of both HR and ABP oscillations and their transfer function may considerably improve the pathophysiological interpretation of cardiovascular autonomic dysfunction in patients with central nervous system disease.

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Citations

Oct 12, 2000·Pacing and Clinical Electrophysiology : PACE·D WichterleM Malík
Jul 28, 2015·International Journal of Molecular Sciences·Alexandra PintérTimo Siepmann
Nov 30, 2013·Progrès en urologie : journal de l'Association française d'urologie et de la Société française d'urologie·G AmarencoE Lapeyre
Feb 7, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·D LindenP Berlit
Nov 29, 2001·Multiple Sclerosis : Clinical and Laboratory Research·P FlacheneckerK V Toyka
Jul 7, 2007·Multiple Sclerosis : Clinical and Laboratory Research·N UzunerN Cinar
Jun 10, 2005·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Emmanuel O SanyaMax J Hilz
Oct 12, 2000·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L KeselbrenerZ Rotstein
Feb 16, 2006·Journal of Neurology·Carl-Albrecht Haensch, Johannes Jörg
Apr 10, 2019·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Mario Habek

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