Autonomic function in amnestic and non-amnestic mild cognitive impairment: spectral heart rate variability analysis provides evidence for a brain-heart axis.

Scientific Reports
Paola NicoliniFederico Lombardi

Abstract

Mild cognitive impairment (MCI) is a heterogeneous syndrome with two main clinical subtypes, amnestic (aMCI) and non-amnestic (naMCI). The analysis of heart rate variability (HRV) is a tool to assess autonomic function. Cognitive and autonomic processes are linked via the central autonomic network. Autonomic dysfunction entails several adverse outcomes. However, very few studies have investigated autonomic function in MCI and none have considered MCI subtypes or the relationship of HRV indices with different cognitive domains and structural brain damage. We assessed autonomic function during an active orthostatic challenge in 253 oupatients aged ≥ 65, [n = 82 aMCI, n = 93 naMCI, n = 78 cognitively normal (CN), neuropsychologically tested] with power spectral analysis of HRV. We used visual rating scales to grade cerebrovascular burden and hippocampal/insular atrophy (HA/IA) on neuroimaging. Only aMCI showed a blunted response to orthostasis. Postural changes in normalised low frequency (LF) power and in the LF to high frequency ratio correlated with a memory test (positively) and HA/IA (negatively) in aMCI, and with attention/executive function tests (negatively) and cerebrovascular burden (positively) in naMCI. These results s...Continue Reading

References

May 15, 1992·Journal of the Autonomic Nervous System·M K Sun
Mar 8, 1987·The Journal of Comparative Neurology·D A RuggieroD J Reis
May 1, 1995·Neurobiology of Aging·H Braak, E Braak
Sep 1, 1994·Age and Ageing·S J WangH C Liu
Oct 1, 1993·The American Journal of Cardiology·M Malik, A J Camm
Jan 17, 1996·Annals of the New York Academy of Sciences·M J de LeonH Wisniewski
May 16, 1998·BMJ : British Medical Journal·T V Perneger
Jan 7, 1999·Alzheimer Disease and Associated Disorders·F GiubileiC Fieschi
Dec 20, 1999·Applied Psychophysiology and Biofeedback·G A Reyes del Paso
May 31, 2001·Brain Research·M J Westerhaus, A D Loewy
Apr 18, 2002·Neurobiology of Aging·Kenneth G Pugh, Lewis A Lipsitz
Aug 3, 2002·Stroke; a Journal of Cerebral Circulation·John Stirling MeyerMinh Quach
Aug 25, 2004·Journal of Internal Medicine·L BäckmanB J Small
Apr 9, 2005·Journal of the American Geriatrics Society·Ziad S NasreddineHoward Chertkow
Oct 11, 2005·Journal of Neuropathology and Experimental Neurology·Daniel J BonthiusGary W Van Hoesen
Jan 10, 2006·Journal of the American Geriatrics Society·Roberto ZulliAlessandro Padovani
Jun 24, 2006·Neuropsychology Review·Julie A Alvarez, Eugene Emory
Sep 11, 2007·The Journal of Neuropsychiatry and Clinical Neurosciences·Donald R RoyallUNKNOWN Committee on Research of the American Neuropsychiatric Association
Aug 19, 2008·Neuroscience and Biobehavioral Reviews·Nicola MontanoFerdinando Iellamo
Mar 17, 2009·Journal of Palliative Medicine·Melissa D A Carlson, R Sean Morrison
May 9, 2009·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Julian F ThayerBjorn Helge Johnsen
Aug 1, 2009·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Samantha GalluzziGiovanni B Frisoni
Oct 9, 2009·Alzheimer Disease and Associated Disorders·Linda L ChaoJulene K Johnson
Dec 8, 2009·Journal of Neurology, Neurosurgery, and Psychiatry·Arto NordlundAnders Wallin
Jul 29, 2010·Pacing and Clinical Electrophysiology : PACE·David NunanDavid A Brodie
Dec 9, 2010·European Journal of Neurology : the Official Journal of the European Federation of Neurological Societies·Y XiongV C T Mok
Feb 15, 2011·Behavioural Brain Research·Michiyo AitakeHisao Nishijo
Feb 25, 2011·Current Opinion in Psychiatry·Tiffany F HughesMary Ganguli
Jul 26, 2011·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Qian ShenRanjan Duara
Apr 5, 2012·Cold Spring Harbor Perspectives in Medicine·Sandra WeintraubDavid P Salmon
May 23, 2012·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Akshya VasudevAlan J Thomas
Oct 30, 2012·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Pieter Jelle VisserPhilip Scheltens
Dec 12, 2012·Journal of the Neurological Sciences·Daniela MateiR Matei
Jan 9, 2013·Nature Reviews. Neurology·Chia-Chen LiuGuojun Bu

❮ Previous
Next ❯

Citations

Oct 20, 2021·International Journal of Psychophysiology : Official Journal of the International Organization of Psychophysiology·Rebecca Johnson ArechavalaXianghong Arakaki

❮ Previous
Next ❯

Methods Mentioned

BETA
genotyping

Software Mentioned

Synescope
R
PSA
SPSS
npsm

Related Concepts

Related Feeds

Alzheimer's Disease: Neuroimaging

Neuroimaging can help identify pathological hallmarks of Alzheimer's disease (AD). Here is the latest research on neuroimaging modalities, including magnetic resonance imaging and positron emission tomography, in AD.

Brain Injury & Trauma

brain injury after impact to the head is due to both immediate mechanical effects and delayed responses of neural tissues.