PMID: 3383812May 1, 1988Paper

Autonomic innervation of pulmonary artery: evidence for a nonadrenergic noncholinergic inhibitory system

Experimental Lung Research
E KubotaS I Said

Abstract

We have investigated the presence and significance of the nonadrenergic noncholinergic relaxant system in isolated strips of guinea pig and cat pulmonary artery (PA), using transmural electrical field stimulation (EFS). Changes in PA strip tension were measured isometrically, in response to EFS with 50-70 V at 20 Hz and pulse durations of 1 or 2 ms. We examined the influence on these responses of alpha- and beta-adrenergic and cholinergic muscarinic receptor blockade, the neurotoxin tetrodotoxin, and the local anesthetic lidocaine. EFS induced an initial brief contraction followed by a slow prolonged relaxation. Phenoxybenzamine, 1.5 X 10(-5) M, greatly reduced the contraction (74.1-87.6% in guinea pig, 65.7-67.4% in cat) and enhanced the subsequent relaxation (23.9-35.5% in guinea pig, 66.8-67.8% in cat). The relaxation was moderately reduced by propranolol, 7.7 X 10(-6) M (30.5-35.0% in guinea pigs, 6.0-21.2% in cat), and by atropine, 1.4 X 10(-6) M (23.7-32.1% in guinea pig, 24.9-40.6% in cat). The major portion of the relaxation, however, persisted in the presence of these blockers. The neurogenic origin of this relaxation was confirmed by its loss with either tetrodotoxin or lidocaine. We conclude that in guinea pig and ca...Continue Reading

References

May 1, 1973·The American Journal of Physiology·R F Coburn, T Tomita
Oct 1, 1974·British Journal of Pharmacology·R A Coleman, G P Levy
Jul 1, 1973·The Journal of General Physiology·G R Strichartz
Jan 1, 1981·Lung·J B Richardson
Mar 12, 1982·European Journal of Pharmacology·S P Duckles, S I Said
Jul 1, 1983·Quarterly Journal of Experimental Physiology : an International Journal of the Physiological Society·A R CameronM C Kirkpatrick
Apr 1, 1984·The Journal of Clinical Investigation·P BiancaniJ Behar
Nov 1, 1984·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·R J AltiereL Diamond
Jun 1, 1983·Journal of Applied Physiology: Respiratory, Environmental and Exercise Physiology·Y HamasakiS I Said
Jan 1, 1980·Annual Review of Physiology·S E Downing, J C Lee
Feb 1, 1980·Journal of Medical Genetics·P Beighton, H Hamersma
Jun 1, 1965·The Journal of Pharmacy and Pharmacology·G PATERSON

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Citations

Feb 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L B Weekley
Mar 11, 2008·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ivan T DemchenkoBarry W Allen
Aug 4, 2001·Nitric Oxide : Biology and Chemistry·B GümüşelS Uma
Jul 2, 2002·Pulmonary Pharmacology & Therapeutics·H I BerishaSami I Said
Apr 10, 2007·American Journal of Physiology. Lung Cellular and Molecular Physiology·Ivan T DemchenkoClaude A Piantadosi
Oct 11, 2008·Journal of Applied Physiology·Barry W AllenClaude A Piantadosi
Feb 3, 2012·Physiological Reviews·J T SylvesterJeremy P T Ward
Apr 1, 1997·Journal of Cardiovascular Pharmacology·R L JonesJ K Ho
Feb 1, 1997·Journal of Applied Physiology·R HaberbergerW Kummer

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