Autonomic innervation of the human middle ear: an immunohistochemical study

American Journal of Otolaryngology
B S Nagaraj, F H Linthicum

Abstract

Although there have been numerous studies of autonomic innervation of the middle ear mucosa, and the mechanism of effusion into the middle ear cavity in animals, the autonomic innervation of the human middle ear has not received much attention. The purpose of this study is to show the presence of catecholaminergic nerve fibers in the human middle-ear mucus membrane that may play an important role in the pathogenesis of middle-ear effusion. A total of 126 celloidin-embedded temporal bone sections from the temporal bone bank at the House Ear Institute were used for immunohistochemical study. A polyclonal antibody to tyrosine hydroxylase enzyme was used to show the presence of catecholaminergic nerve fibers. Tyrosine hydroxylase immunoreactive nerve fibers containing numerous fine varicosities along their course, characteristic of noradrenergic neurons, were observed throughout the middle-ear mucosa including the promontary, sinus tympani, mesotympanum, and hypotympanum. In addition, these nerve fibers were seen in close promixity to the small-caliber blood vessels. A striking variation in the intensity of staining as well as in the amount of nerve fibers was observed among the temporal bone sections. It is possible that the catec...Continue Reading

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Citations

May 27, 2010·Journal of the Association for Research in Otolaryngology : JARO·Stéphane F MaisonM Charles Liberman
Sep 27, 2018·Trends in Hearing·Arnaud J NoreñaNicolas Charpentier
Sep 2, 2017·Frontiers in Neurology·Alain LonderoArnaud J Noreña
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