Autonomic mechanisms in hemodynamic responses to isometric exercise

The Journal of Clinical Investigation
C E MartinJ J Leonard


Selective autonomic blockade with intravenous propranolol, practolol, atropine, and combined atropine-propranolol was utilized to elucidate the role of the autonomic nervous system in the hemodynamic responses in young adult male volunteers to handgrip sustained at 30% of maximal voluntary contraction for 3 min. The initial 30 s of the tachycardia response was found to be mediated by withdrawal of vagal dominance, as evidenced by blockade of this response by prior atropinization. The mid and late portion of the heart rate response curve was demonstrated to be sympathetic in origin, since it was unaffected by atropine, but was suppressed by combined atropine-propranolol blockade. Sympathetic stimulation appears to be a secondary mechanism for increasing the heart rate, however, as it becomes operative only after the first mechanism of vagal withdrawal has been utilized. This was confirmed by the finding that beta adrenergic receptor blockade alone had little effect on the heart rate response curve. The pressor response to handgrip was accompanied by increased cardiac output and no change in calculated systemic vascular resistance. After propranolol, handgrip resulted in increased peripheral resistance and an equivalent rise in a...Continue Reading


Apr 1, 1973·British Heart Journal·D J EwingB J Kirby
Jan 1, 1968·British Journal of Pharmacology and Chemotherapy·D Dunlop, R G Shanks
Aug 1, 1971·Annals of Internal Medicine
Jan 1, 1972·Circulation·D F LeonR H McDonald
Jan 1, 1972·British Heart Journal·D G Gibson, D J Coltart
Mar 1, 1973·The American Journal of Cardiology·D H JacksonJ Burdeshaw
Mar 1, 1972·The American Journal of Cardiology·H P KrayenbuehlI Amende
Apr 1, 1971·The American Journal of the Medical Sciences·M N Frank, N Haberern
Apr 1, 1970·The American Journal of Cardiology·C C MetzgerJ J Leonard
Dec 1, 1970·American Heart Journal·D F LeonJ J Leonard
Apr 1, 1971·The American Journal of Cardiology·R C TalleyJ L McNay
Apr 1, 1969·The American Journal of Cardiology·A M WeisslerC D Schoenfeld
Nov 1, 1965·The Journal of Clinical Investigation·S E EpsteinE Braunwald
Sep 1, 1966·The American Journal of Cardiology·H R MacDonaldK W Donald
Feb 1, 1964·Circulation Research·R D JONES, R M BERNE


Jan 1, 1980·European Journal of Applied Physiology and Occupational Physiology·J SanchezH Monod
Dec 6, 1976·European Journal of Applied Physiology and Occupational Physiology·A Kilbom, T Brundin
Jan 1, 1983·European Journal of Applied Physiology and Occupational Physiology·J Sanchez, P Sébert
Jul 2, 1979·European Journal of Applied Physiology and Occupational Physiology·K NazarZ Zukowska-Grójec
Dec 22, 1977·European Journal of Applied Physiology and Occupational Physiology·R H Robson, D C Fluck
Feb 1, 1987·Pflügers Archiv : European journal of physiology·B C MacielL E Martins
Jan 1, 1994·European Journal of Applied Physiology and Occupational Physiology·T N JacobsenO Amtorp
Aug 1, 1992·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·C Cotzias, J M Marshall
Aug 1, 1996·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·R K Khurana, A Setty
Jan 1, 1989·European Journal of Applied Physiology and Occupational Physiology·R GruczaK Nazar
Apr 23, 2008·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·C MihlH Kuipers
Jun 8, 2007·European Journal of Applied Physiology·Bernd JohannesRupert Gerzer
Jun 11, 2008·European Journal of Applied Physiology·Omri InbarB J Whipp
Jul 29, 2011·European Journal of Applied Physiology·K KrzemińskiK Nazar
May 31, 2012·European Journal of Applied Physiology·Konrad BinderGlen P Kenny
May 1, 1994·Respiration Physiology·A BreitenbücherA Wanner
Apr 1, 1979·Mechanisms of Ageing and Development·F C YinM L Weisfeldt
Jan 1, 1996·European Journal of Obstetrics, Gynecology, and Reproductive Biology·E M Ekholm, R U Erkkola
Jul 1, 1995·Progress in Cardiovascular Diseases·J M Delehanty, C S Liang
Feb 1, 2003·International Journal of Cardiology·José Kawazoe LazzoliClaudio Gil Soares de Araújo
May 1, 2010·Journal of Human Genetics·Vishnu Sarpeshkar, David J Bentley
Sep 5, 2006·The International Journal of Clinical and Experimental Hypnosis·Richard C RobinsonTravis Whitfill
Apr 1, 1979·British Journal of Clinical Pharmacology·D N BatemanC T Dollery
Nov 1, 1992·Acta Anaesthesiologica Scandinavica·J JacobsenN H Secher
Nov 1, 1992·Clinical and Experimental Pharmacology & Physiology·N H SecherS Matzen
Mar 1, 1989·British Heart Journal·S C RobsonR S Bexton
Jul 1, 1981·The Journal of Clinical Investigation·F C YinW R Milnor
Apr 17, 2002·Circulation Journal : Official Journal of the Japanese Circulation Society·Yukio NakamuraYasushi Matsumoto
Feb 14, 2014·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·L R A Olde NordkampA A Wilde
Mar 11, 2005·Archives of Physical Medicine and Rehabilitation·Takeshi NakamuraFumihiro Tajima
Aug 1, 1997·Cardiology Clinics·J C Longhurst, C L Stebbins
Sep 5, 2009·Annals of Behavioral Medicine : a Publication of the Society of Behavioral Medicine·Blaine DittoC D Holly
Jan 1, 1981·Clinical and Experimental Hypertension : CHE·S G ChrysantK Danisa
Feb 10, 2010·The Journal of Physiology·James P FisherPaul J Fadel
Jun 4, 2013·Vox Sanguinis·Blaine DittoC R France
Mar 16, 2012·Psychophysiology·Philippe T Gilchrist, Blaine Ditto
Jun 1, 1991·The American Journal of Cardiology·G S Butrous, A J Camm
Mar 26, 2016·Journal of Science and Medicine in Sport·Jason M ConviserD Paul Thomas
Jun 10, 2015·IEEE Transactions on Bio-medical Engineering·Ramakrishna MukkamalaSurvi Kyal
Jun 5, 1989·The American Journal of Cardiology·E GrossmanA A MacPhee
Feb 14, 2006·Autonomic Neuroscience : Basic & Clinical·Yujiro Yamanaka, Koichi Honma
Feb 13, 2015·Heart·Vasiliki Manou-StathopoulouRupert P Williams
Nov 6, 2010·Journal of the American College of Cardiology·Francis J Klocke
Apr 22, 2016·The Journal of Physiology·Michael J Joyner
Oct 1, 2016·The Journal of Physiology·Khadigeh El SayedChloe E Taylor
Jan 1, 1983·Hypertension·A M ShepherdT K Keeton
Oct 26, 2005·International Journal of Obesity : Journal of the International Association for the Study of Obesity·L M UenoC E Negrão
Nov 15, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Masashi IchinoseTakeshi Nishiyasu
Dec 1, 1981·The British Journal of Psychiatry : the Journal of Mental Science·E A TaylorP Turner
Nov 12, 2013·American Journal of Physiology. Heart and Circulatory Physiology·Kazuhito WatanabeTakeshi Nishiyasu
Mar 5, 2020·American Journal of Hypertension·Yuichiro YanoAndrew Sherwood
Aug 17, 2018·Clinical Journal of Sport Medicine : Official Journal of the Canadian Academy of Sport Medicine·Emilie WoehrleJoel Kevin Shoemaker
May 1, 1986·British Heart Journal·E NylanderB Wranne
Sep 18, 1997·Journal of Applied Physiology·A C NóbregaJ H Mitchell
Oct 22, 2002·American Journal of Physiology. Heart and Circulatory Physiology·Christopher W MyersJ Andrew Taylor
Sep 2, 1998·The American Journal of Physiology·J SpaakD Linnarsson
Jul 5, 2005·Journal of Applied Physiology·John H EisenachMichael J Joyner
Oct 20, 2000·Medicine and Science in Sports and Exercise·R González-CamarenaJ Azpiroz-Leehan
Apr 25, 2018·Heart Failure Reviews·Dario GrandeNadia Aspromonte
Feb 6, 1998·Journal of Applied Physiology·S Mostoufi-MoabL I Sinoway

Related Concepts

Atropine Sulfate Anhydrous
Diastolic Blood Pressure
Cardiac Output
Clinical Trials
Pulse Rate
Vagus Nerve Structure

Related Feeds

Adrenergic Receptors: Trafficking

Adrenergic receptor trafficking is an active physiological process where adrenergic receptors are relocated from one region of the cell to another or from one type of cell to another. Discover the latest research on adrenergic receptor trafficking here.