PMID: 2511237Oct 1, 1989Paper

Autonomic nerve and cardiovascular responses to changing blood oxygen and carbon dioxide levels in the rat

Journal of the Autonomic Nervous System
Y FukudaA Trzebski

Abstract

Contribution of autonomic nervous system activity to the heart rate and blood pressure responses during chemoreceptor excitations by systemic hypoxia and hypercapnia and to hyperoxia and hypocapnia was analyzed in the urethane-anesthetized, artificially ventilated rats. Systemic hypoxia induced a co-activation of two antagonistic nerves: an increase in cardiac sympathetic and in cardiac vagal efferent nerve discharges. Increased heart rate was due to predominance of the cardiac sympathetic over the cardiac vagal activation. In spite of a marked reflex increase in the renal and cardiac sympathetic nerve activities, the local vasodilator effect of hypoxia prevented consistent changes in arterial blood pressure. Bilateral section of the carotid sinus nerves (CSN) mostly abolished autonomic nerve responses and produced a profound decreases in the blood pressure during hypoxia. Hyperoxia elicited a pressor response due to peripheral vasoconstriction with no significant change in the autonomic nerve activities except for a decrease in the cardiac sympathetic nerve discharges. Hypercapnia significantly increased blood pressure and renal nerve sympathetic activity. In contrast to hypoxia, hypercapnia excited cardiac sympathetic and inh...Continue Reading

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Citations

Jan 5, 1996·Journal of the Autonomic Nervous System·M L SmithK P Strohl
Oct 1, 1994·Progress in Neurobiology·M K Sun, D J Reis
Feb 6, 2004·Progress in Neurobiology·R A L Dampney, J Horiuchi
Jun 17, 1998·Respiration Physiology·K SugitoT Kuriyama
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Jan 1, 1994·Psychophysiology·G G BerntsonV T Fabro
May 13, 2010·Autonomic Neuroscience : Basic & Clinical·Sae UchidaHarumi Hotta
Aug 5, 2009·Autonomic Neuroscience : Basic & Clinical·Harumi HottaMark Stewart
Nov 26, 2008·The Journal of Comparative Neurology·Antón Barreiro-IglesiasMaría Celina Rodicio
Sep 4, 2015·Depression and Anxiety·Philip L JohnsonAnantha Shekhar
Jan 25, 2005·Autonomic Neuroscience : Basic & Clinical·Shigeru OikawaYoshiaki Hayashida
Jun 30, 2006·European Journal of Pharmacology·Harumi HottaKimiko Murakami-Murofushi
Jan 6, 2004·Experimental and Toxicologic Pathology : Official Journal of the Gesellschaft Für Toxikologische Pathologie·Kathrin BauerReinhard Bauer
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