Autonomic nerve stimulation, kallikrein content anc acinar cell granules of the cat's submandibular gland.

The Journal of Physiology
S BartonM Uddin

Abstract

The parasympathetic and sympathetic nerves to the submandibular gland of the anaesthetized cat were stimulated under specific conditions. 1. It was possible to decrease the kallikrein (kininogenase) content of the gland by as much as 90-95% by sympathetic nerve stimulation. In such a gland the appearance and concentration of secretory granules in the acinar cells were indistinguishable from an unstimulated gland. 2. Parasympathetic nerve stimulation, in contrast to sympathetic nerve stimulation, whilst having no significant effect on the kininogenase content of the gland, resulted in the disappearance of a great majority of the acinar granules. 3. These results demonstrate that the acinar granules in the submandibular gland of the cat are not a significant source of kallikrein. 4. Our experiments also failed to indicate any obvious correlation between the granules of the demilune cells and the kallikrein content of the gland. 5. The possibility is raised that kallikrein is located in the cells of the striated ducts.

Citations

Oct 1, 1984·Agents and Actions·G BönnerF Gross
Jul 1, 1994·Journal of the Autonomic Nervous System·H Izumi, K Karita
Dec 1, 1978·Acta Physiologica Scandinavica·T B Orstavik
May 1, 1977·Acta Physiologica Scandinavica·T B Orstavik, K M Gautvik
Jan 1, 1978·General Pharmacology·K NustadJ V Pierce
May 8, 1978·Life Sciences·M Uddin, W Tyler

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