Autonomic nerve trauma at radical hysterectomy: the nerve content and subtypes within the superficial and deep uterosacral ligaments

Reproductive Sciences
S A Butler-ManuelDesmond P J Barton

Abstract

The authors previously demonstrated nerve trunks and autonomic ganglia of the hypogastric plexus within the uterosacral ligament (USL) and the cardinal ligaments. The nerve content of these ligaments is greatest closer to the pelvic sidewalls and diminishes toward the insertion of the ligaments into the uterus, with the greater nerve content in the USL. Here the authors determine whether the nerve content of the superficial and deep portion of the USLs, where they are divided at a radical hysterectomy, differ. Biopsies were taken from the right and left superficial and deep USL in 6 patients during radical hysterectomy for early-stage cervical cancer. Indirect immunofluorescence was performed using primary antibodies to (1) the panneuronal marker PGP 9.5, (2) the parasympathetic marker vasoactive intestinal peptide, (3) the sympathetic markers tyrosine hydroxylase and neuropeptide-Y, (4) the sensory and nociceptive nerve marker substance P, and (5) the sensory and sensory-motor nerve marker calcitonin gene-related peptide. The percentage area of immunoreactivity (PAI) was determined using a computer-assisted image analyzer as an objective measure of nerve content. There was a lower nerve content in the superficial USL compared ...Continue Reading

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Citations

May 12, 2010·International Urogynecology Journal·Dzung VuAnnabelle Farnsworth
May 24, 2012·International Urogynecology Journal·Rajeev RamanahJohn O L DeLancey
Nov 10, 2009·Journal de gynécologie, obstétrique et biologie de la reproduction·A-S BatsF Lécuru
Oct 16, 2013·Gynecologic Oncology·C BonneauC Touboul
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Dec 24, 2014·Surgical and Radiologic Anatomy : SRA·Haili LiHuixian Cui
Apr 20, 2016·International Urogynecology Journal·Ritsuko IwanagaKathleen A Connell
Sep 25, 2012·American Journal of Obstetrics and Gynecology·Rajeev RamanahJohn O L Delancey
Nov 12, 2013·European Journal of Obstetrics, Gynecology, and Reproductive Biology·Chunlin ChenKenneth Hatch
Jun 23, 2010·Journal of Inherited Metabolic Disease·Eleni TsitsiouJocelyn D Glazier
Mar 5, 2009·International Journal of Gynecological Cancer : Official Journal of the International Gynecological Cancer Society·Desmond P J Barton, Desiree F Kolomainen
Apr 11, 2019·Obstetrics and Gynecology·Lindsey A JacksonMarlene M Corton
Jul 28, 2018·Annals of Biomedical Engineering·Adwoa Baah-DwomohRaffaella De Vita

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