PMID: 184880Oct 22, 1976Paper

Autonomic nerves, mast cells, and amine receptors in human brain vessels. A histochemical and pharmacological study

Brain Research
L EdvinssonN O Sjöberg


The studies were performed on operation material from 17- to 63-year-old patients and on fetuses at 19-23 weeks gestational age. Formaldehyde histofluorescence showed the presence of numerous perivascular adrenergic nerves around pial and intracerebral vessels, the carotid system being better supplied than the vertebral system. Cholinergic nerves, visualized by the cholinesterase technique, followed the adrenergic fibers in the plexus formations of the pial arterial system. Histamine-containing mast cells, often with a perivascular distribution, were located with the o-phthaldiadehyde method. Transmural electrical stimulation of the perivascular nerves contracted isolated pieces of pial arteries in a frequency-dependent manner, and the response was inhibited by the adrenergic nerve blocking agent, guanethidine. On the basis of the relative potency of various amines and related compounds in producing a motor response of isolated pial arteries, and the mode of inhibition caused by specific antagonists, various amine receptors could be demonstrated: adrenergic alpha-receptors (mediating contraction) and beta-receptors (dilation), cholinergic muscarinic receptors (dilation) and histamine H2-receptors (mediating dilation). Thus, the...Continue Reading


Jan 1, 1970·Brain : a Journal of Neurology·E Nelson, M Rennels
Jan 1, 1974·Blood Vessels·C OwmanK C Nielsen
Oct 1, 1973·Agents and Actions·A L RönnbergC Owman
Sep 1, 1973·Stroke; a Journal of Cerebral Circulation·J A Bevan, R D Bevan
Nov 22, 1974·Brain Research·M J Hernández-Pérez, H L Stone
Jul 1, 1969·Circulation Research·I M JamesM J Purves
Aug 1, 1972·Circulation Research·L G D'Alecy, E O Feigl
Jul 1, 1972·Journal of Neuropathology and Experimental Neurology·E NelsonJ Kawamura
Jan 16, 1970·Science·E Nelson, M Rennels
Oct 1, 1970·Acta Physiologica Scandinavica·J De ChamplainC Sachs
Jan 1, 1970·Zeitschrift für Zellforschung und mikroskopische Anatomie·T Iwayama
Mar 1, 1968·The Journal of General Physiology·L BarrM M Dewey
Jan 1, 1968·Scandinavian Journal of Clinical and Laboratory Investigation. Supplementum·B FalckC Owman
Jun 1, 1960·Journal of Ultrastructure Research·D C PEASE, S MOLINARI

❮ Previous
Next ❯


Jul 1, 1980·Naunyn-Schmiedeberg's Archives of Pharmacology·E J MarcoS Lluch
Jul 1, 1985·Neuroscience and Behavioral Physiology· Pigolkin YuIP A Motavkin
Sep 1, 1982·Klinische Wochenschrift·J K KhandelwalJ P Green
May 25, 2005·Annals of Nuclear Medicine·Hiroshi ItoHiroshi Fukuda
Feb 6, 2008·Archives of Gynecology and Obstetrics·Wei-Xia PengHirobumi Asakura
Feb 10, 2009·Neurological Sciences : Official Journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology·E MediciE Giaccaglini
Mar 28, 2008·Current Oncology Reports·Christopher VaughnDavid Schiff
Mar 17, 2001·Current Pain and Headache Reports·L Edvinsson
Apr 1, 1995·American Journal of Obstetrics and Gynecology·F G CunninghamC Hernandez
Jan 1, 1981·Electroencephalography and Clinical Neurophysiology·D AncriJ Y Basset
Jun 15, 1979·European Journal of Pharmacology·T M GalenoM J Brody
Jul 20, 1984·European Journal of Pharmacology·G A LambertJ W Lance
Mar 1, 1989·Journal of the Neurological Sciences·S MohantyY Olsson
Jan 1, 1995·Pharmacology & Therapeutics·F Dauphin, E T MacKenzie
Sep 1, 1994·Journal of the Autonomic Nervous System·L EdvinssonS Gulbenkian
Feb 1, 1980·Neuroscience Letters·F AmentaF Ferrante
Jan 1, 1982·General Pharmacology·J Marín, F Rivilla
Jan 1, 1983·General Pharmacology·J A Bevan
Jun 18, 2005·Brain Research. Brain Research Reviews·Theoharis C TheoharidesAphrodite Konstantinidou
Nov 30, 2000·Survey of Ophthalmology·A J ParkH V Danesh-Meyer

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.


Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.