Vascularization and innervation of the islet of Langerhans are highly interconnected and are critical for intercellular and intertissular communication. They are both involved in the control of islet blood flow which has been shown to have an important role in the control of endocine secretion. Both parameters are disturbed during the course of metabolic pathologies and particularly diabetes. A better understanding of these mechanisms has and will greatly benefit from the rapidly-emerging technologies particularly in vivo imaging enabling to study both anatomy and functions of the islet.
A rapid method of visualizing the pancreatic islets for studies of islet capillary blood flow using non-radioactive microspheres
A specific beta 3-adrenoceptor agonist induces increased pancreatic islet blood flow and insulin secretion in rats
Increased pancreatic islet blood flow in 48-hour glucose-infused rats: involvement of central and autonomic nervous systems
Pancreatic insulo-acinar portal systems in humans, rats, and some other mammals: scanning electron microscopy of vascular casts
Pancreatic islet blood perfusion in the nonobese diabetic mouse: diabetes-prone female mice exhibit a higher blood flow compared with male mice in the prediabetic phase
Relationships between the autonomic nervous system and the pancreas including regulation of regeneration and apoptosis: recent developments
Real-time, multidimensional in vivo imaging used to investigate blood flow in mouse pancreatic islets
Three-dimensional optical method for integrated visualization of mouse islet microstructure and vascular network with subcellular-level resolution
Vascular labeling of luminescent gold nanorods enables 3-D microscopy of mouse intestinal capillaries
Two-week treatment with the β₃-adrenoceptor antagonist SR59230A normalizes the increased pancreatic islet blood flow in type 2 diabetic GK rats
3-D imaging and illustration of the perfusive mouse islet sympathetic innervation and its remodelling in injury.
Noninvasive in vivo model demonstrating the effects of autonomic innervation on pancreatic islet function
Sympathetic innervation during development is necessary for pancreatic islet architecture and functional maturation
The use of hydrogen gas clearance for blood flow measurements in single endogenous and transplanted pancreatic islets
Whole-body and Whole-Organ Clearing and Imaging Techniques with Single-Cell Resolution: Toward Organism-Level Systems Biology in Mammals
Label-free fast 3D coherent imaging reveals pancreatic islet micro-vascularization and dynamic blood flow
Integrated Pancreatic Blood Flow: Bidirectional Microcirculation Between Endocrine and Exocrine Pancreas.
Implications of Integrated Pancreatic Microcirculation: Crosstalk between Endocrine and Exocrine Compartments.
Autonomic nervous system activity changes in patients with hypertension and overweight: role and therapeutic implications.
Autoimmune Diabetes & Tolerance
Patients with type I diabetes lack insulin-producing beta cells due to the loss of immunological tolerance and autoimmune disease. Discover the latest research on targeting tolerance to prevent diabetes.