Autonomic nervous system dysfunction and inflammation contribute to the increased cardiovascular mortality risk associated with depression.

Psychosomatic Medicine
Willem J KopJohn S Gottdiener

Abstract

To investigate prospectively whether autonomic nervous system (ANS) dysfunction and inflammation play a role in the increased cardiovascular disease (CVD)-related mortality risk associated with depression. Participants in the Cardiovascular Health Study (n = 907; mean age, 71.3 ± 4.6 years; 59.1% women) were evaluated for ANS indices derived from heart rate variability (HRV) analysis (frequency and time domain HRV, and nonlinear indices, including detrended fluctuation analysis (DFA(1)) and heart rate turbulence). Inflammation markers included C-reactive protein, interleukin-6, fibrinogen, and white blood cell count). Depressive symptoms were assessed, using the 10-item Centers for Epidemiological Studies Depression scale. Cox proportional hazards models were used to investigate the mortality risk associated with depression, ANS, and inflammation markers, adjusting for demographic and clinical covariates. Depression was associated with ANS dysfunction (DFA(1), p = .018), and increased inflammation markers (white blood cell count, p = .012, fibrinogen p = .043) adjusting for covariates. CVD-related mortality occurred in 121 participants during a median follow-up of 13.3 years. Depression was associated with an increased CVD mort...Continue Reading

References

Feb 1, 1991·Annals of Epidemiology·L P FriedA Newman
Dec 1, 1993·American Journal of Epidemiology·G Maldonado, S Greenland
May 1, 1993·Psychological Bulletin·T B Herbert, S Cohen
Jun 1, 1997·American Journal of Epidemiology·D S SiscovickD H O'Leary
Jul 1, 1997·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·C H HirschR Schulz
Dec 24, 1997·Psychophysiology·G G BerntsonM W van der Molen
May 21, 1999·The American Journal of Medicine·T B HarrisR Wallace
Feb 7, 2001·American Journal of Epidemiology·D F GeffkenR P Tracy
Apr 25, 2001·Circulation·M T La RovereUNKNOWN ATRAMI Investigators. Autonomic Tone and Reflexes After Myocardial Infarcton
Aug 18, 2001·Italian heart journal. Supplement : official journal of the Italian Federation of Cardiology·M V Pitzalis
Aug 10, 2002·JAMA : the Journal of the American Medical Association·Alexander H GlassmanUNKNOWN Sertraline Antidepressant Heart Attack Randomized Trial (SADHEART) Group
Dec 17, 2002·Arteriosclerosis, Thrombosis, and Vascular Biology·Nancy S JennySteve E Humphries
Dec 20, 2002·Nature·Kevin J Tracey
Jun 19, 2003·JAMA : the Journal of the American Medical Association·Lisa F BerkmanUNKNOWN Enhancing Recovery in Coronary Heart Disease Patients Investigators (ENRICHD)
Jan 28, 2005·Journal of Cardiovascular Electrophysiology·Phyllis K SteinUNKNOWN Cast Investigators
May 25, 2005·Psychosomatic Medicine·Willem J KopAlan Rozanski
Jun 15, 2005·Psychosomatic Medicine·Willem J Kop, John S Gottdiener
Jul 13, 2005·Circulation·Mikko P TulppoHeikki V Huikuri
Jun 13, 2006·The American Journal of Cardiology·Gaetano A LanzaUNKNOWN SPAI (Stratificazione Prognostica dell'Angina Instabile) Investigators
Dec 15, 2006·Psychosomatic Medicine·Robert M CarneyAllan S Jaffe
Dec 29, 2006·Annals of the New York Academy of Sciences·Julian F Thayer, Esther Sternberg
Jan 12, 2007·American Journal of Epidemiology·Nancy Swords JennyRussell P Tracy
Jan 24, 2007·Archives of Internal Medicine·Nalini RanjitHanyu Ni
Mar 27, 2007·Journal of Psychosomatic Research·Robert M CarneyStephen P Duntley
Mar 29, 2007·Journal of Thrombosis and Haemostasis : JTH·N A ZakaiM Cushman
Jun 2, 2007·The British Journal of Psychiatry : the Journal of Mental Science·Joost P van MelleUNKNOWN MIND-IT investigators

❮ Previous
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Citations

Feb 2, 2013·Europace : European Pacing, Arrhythmias, and Cardiac Electrophysiology : Journal of the Working Groups on Cardiac Pacing, Arrhythmias, and Cardiac Cellular Electrophysiology of the European Society of Cardiology·Stefanie HillebrandOlaf M Dekkers
Apr 6, 2011·Cardiology in Review·Christopher M Celano, Jeff C Huffman
Jun 6, 2012·Current Gerontology and Geriatrics Research·Lilian ThorpeJosephine Nanson
Mar 30, 2013·Annual Review of Clinical Psychology·Mary A Whooley, Jonathan M Wong
Oct 27, 2011·International Journal of Hypertension·Mark HamerLeoné Malan
Nov 6, 2012·Current Cardiovascular Risk Reports·Siqin YeKarina W Davidson
Sep 10, 2013·Endocrinology and Metabolism Clinics of North America·François PouwerArie Nouwen
Feb 28, 2015·Journal of Psychosomatic Research·Roy C Ziegelstein
Sep 8, 2011·Depression and Anxiety·Jose M MartinezJack M Gorman
Jan 11, 2012·Pacing and Clinical Electrophysiology : PACE·Alaa ShalabySamir Saba
Mar 15, 2015·Brain, Behavior, and Immunity·Uté Vollmer-ConnaGordon Parker
May 9, 2013·Cardiovascular Psychiatry and Neurology·Jeff C HuffmanJames L Januzzi
Jun 16, 2012·Progress in Neuro-psychopharmacology & Biological Psychiatry·Jae Seung ChangTaesung Park
Apr 25, 2013·Journal of cardiology·Valentina N NikolicSlobodan M Jankovic
Apr 30, 2013·Progress in Cardiovascular Diseases·Larkin Elderon, Mary A Whooley
Jun 14, 2013·The International Journal of Neuropsychopharmacology·Andre Russowsky BrunoniIsabela M Benseñor
Oct 11, 2014·Burns : Journal of the International Society for Burn Injuries·Daniele Walter DuarteElisabete Seganfredo Weber
Oct 19, 2016·The American Journal of Geriatric Psychiatry : Official Journal of the American Association for Geriatric Psychiatry·Giulio ToniUNKNOWN SEEDS study group
Aug 20, 2016·Medical & Biological Engineering & Computing·A H KhandokerH F Jelinek
Mar 23, 2012·Journal of cardiology·Mario A CaroJeff C Huffman
Nov 12, 2016·Preventive Medicine·Mandy Xian HuBrenda W J H Penninx
Nov 18, 2016·Nature Reviews. Cardiology·Robert M Carney, Kenneth E Freedland
Jul 30, 2015·The Australian and New Zealand Journal of Psychiatry·Isabelle Granville SmithUté Vollmer-Conna
Mar 30, 2018·Physiological Measurement·Alberto GrecoGaetano Valenza
Feb 1, 2018·Stress : the International Journal on the Biology of Stress·Ross W MayFrank D Fincham
Oct 5, 2017·Journal of Clinical Psychology in Medical Settings·Stefanie StauberRoland von Känel

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