Autonomic nervous system imbalance and left ventricular systolic dysfunction as potential candidates for arrhythmogenesis in Becker muscular dystrophy

International Journal of Cardiology
V DucceschiA Iacono

Abstract

We evaluated the arrhythmic profile in a population of 20 Becker muscular dystrophy (BMD) patients searching for possible correlations between the severity of the arrhythmic events, the cardiac autonomic balance (assessed by heart rate variability analysis in the time domain) and the degree of left ventricular systolic impairment. A population of 14 male healthy individuals served as the control group. BMD subjects exhibited lower values of SDNN (P=0.013), SDANN index (P=0.008) and 24-h mean heart rate (P=0.002). The total number of premature ventricular beats (totPVB) and the number of PVB out of 1000 heartbeats (PVB/1000) appeared also higher in BMD subjects (P=0.05 and P=0.046, respectively). No difference was found in terms of 24-h mean QTc and 24-h longest QT among the two groups. TotPVB and PVB/1000 were inversely related to both the ejection fraction (r= -0.620, P=0.004 and r= -0.517, P=0.019) and to the shortening fraction (r= -0.568, P=0.009 and r= -0.469, P=0.037). Twenty-four-h mean QTc was also inversely related to both the ejection fraction (r= -0.520, P=0.019) and the fractional shortening (r= -0.491, P=0.028). These data suggest that in BMD there is cardiac autonomic imbalance characterized by sympathetic predomi...Continue Reading

References

Sep 1, 1992·British Heart Journal·S E SteareA Benatar
Aug 15, 1992·The American Journal of Cardiology·C M Dougherty, R L Burr
Apr 1, 1991·American Heart Journal·B Brembilla-PerrotY Juillière
Mar 1, 1990·International Journal of Cardiology·G NigroR J Bain
Sep 1, 1983·Journal of the American College of Cardiology·J R WilsonM E Josephson
Feb 1, 1984·British Heart Journal·K von OlshausenW Kübler
Mar 15, 1984·The American Journal of Cardiology·T MeinertzJ Meyer
Nov 1, 1995·The American Journal of Cardiology·M YotsukuraK Ishikawa
Nov 1, 1995·Muscle & Nerve·F PisanoP Pinelli
Mar 1, 1995·Muscle & Nerve·G NigroB Restucci
Dec 1, 1994·British Heart Journal·M BorggrefeG Breithardt
Aug 1, 1994·European Heart Journal·E G VesterB E Strauer
Jan 1, 1993·Current Opinion in Cardiology·D BöckerG Breithardt

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Citations

Sep 1, 2000·Journal of Molecular and Cellular Cardiology·S Lu, A Hoey
Jun 20, 2001·Journal of the Neurological Sciences·G VitaC Messina
Oct 9, 2008·The Canadian Journal of Cardiology·Josef Finsterer, Claudia Stöllberger
Aug 26, 2017·Circulation·Brian FeingoldUNKNOWN American Heart Association Pediatric Heart Failure Committee of the Council on Cardiovascular Disease in the Young; Council
Jun 7, 2005·Muscle & Nerve·Fiona C Goodwin, Francesco Muntoni
Jun 6, 2017·Intractable & Rare Diseases Research·Andrea Antonio PapaLuisa Politano
Oct 3, 2006·Current Opinion in Anaesthesiology·F Le Corre, B Plaud

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