Autonomic pathophysiology in heart failure patients. Sympathetic-cholinergic interrelations

The Journal of Clinical Investigation
T R PorterP K Mohanty


We conducted this study in an effort to characterize and understand vagal abnormalities in heart failure patients whose sympathetic activity is known. We measured sympathetic (peroneal nerve muscle sympathetic recordings and antecubital vein plasma norepinephrine levels) and vagal (R-R intervals and their standard deviations) activities in eight heart failure patients and eight age-matched healthy volunteers, before and after parasympathomimetic and parasympatholytic intravenous doses of atropine sulfate. At rest, sympathetic and parasympathetic outflows were related reciprocally: heart failure patients had high sympathetic and low parasympathetic outflows, and healthy subjects had low sympathetic and high parasympathetic outflows. Low dose atropine, which is known to increase the activity of central vagal-cardiac motoneurons, significantly increased R-R intervals in healthy subjects, but did not alter R-R intervals in heart failure patients. Thus, our data document reciprocal supranormal sympathetic and subnormal parasympathetic outflows in heart failure patients and suggest that these abnormalities result in part from abnormalities within the central nervous system.


Feb 1, 1978·The American Journal of Cardiology·J A Thomas, B H Marks
Aug 1, 1979·Angiology·D V CokkinosC D Gardikas
Jul 1, 1989·Journal of the American College of Cardiology·M L SmithM D Thames
Mar 1, 1988·British Journal of Clinical Pharmacology·G B KondoweD W Harron
Jun 1, 1988·Acta Physiologica Scandinavica·D L EckbergB G Wallin
Aug 1, 1986·The Journal of Clinical Investigation·D L EckbergD F Gardner
Jun 1, 1985·Brain : a Journal of Neurology·J FagiusS Englesson
Jan 1, 1970·Naunyn-Schmiedebergs Archiv Für Pharmakologie·K Löffelholz, E Muscholl
Nov 1, 1971·Circulation Research·M N Levy
Oct 14, 1971·The New England Journal of Medicine·D L EckbergE Braunwald
Oct 1, 1969·Circulation·W BeckV Schrire
Dec 23, 1971·The New England Journal of Medicine·P A McKeeW B Kannel
Nov 1, 1969·The Journal of Clinical Investigation·A D Jose, R R Taylor
Sep 1, 1983·Journal of the American College of Cardiology·J R WilsonM E Josephson
Jul 22, 1982·The New England Journal of Medicine·M R BristowE B Stinson
Sep 27, 1984·The New England Journal of Medicine·J N CohnT Rector
Apr 1, 1984·IEEE Transactions on Bio-medical Engineering·R W DeBoerJ Strackee
Feb 1, 1981·Circulation·A FerrariG Mancia

❮ Previous
Next ❯


Jun 5, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·Y B SverrisdóttirM Elam
May 27, 2010·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·Miyuki AndoMasunori Matsuzaki
Apr 1, 1994·European Journal of Obstetrics, Gynecology, and Reproductive Biology·O SibonyP Blot
Mar 1, 1994·Journal of the Autonomic Nervous System·M KollaiA Naszlady
Apr 20, 1996·Journal of the Autonomic Nervous System·V A MoguilevskiB P McGrath
Oct 1, 1993·Journal of the American College of Cardiology·J S Floras
Mar 1, 1995·Journal of the American College of Cardiology·G C ButlerJ S Floras
Feb 1, 1994·Journal of the American College of Cardiology·M A Creager, S J Creager
Mar 1, 1994·Journal of the American College of Cardiology·M A WooH R Middlekauff
Jun 14, 2000·European Journal of Pharmacology·O Saetrum OpgaardL Edvinsson
Aug 12, 1999·European Journal of Pharmacology·C GiesslerO E Brodde
Dec 23, 1999·European Journal of Pharmacology·O Saetrum OpgaardP R Saxena
May 1, 1995·Progress in Cardiovascular Diseases·I H ZuckerK P Patel
Mar 28, 2002·Pharmacology & Therapeutics·A A ArmoundasG F Tomaselli
Apr 28, 2000·Journal of the Autonomic Nervous System·T M Saleh, B J Connell
Mar 17, 1999·International Journal of Cardiology·T HayanoM Matsuzaki
Nov 26, 2002·Journal of the American College of Cardiology·Mark T KearneyJames Nolan
Dec 1, 1996·Journal of the American College of Cardiology·J A TaylorK A Ellenbogen
Feb 10, 1998·Journal of Nuclear Cardiology : Official Publication of the American Society of Nuclear Cardiology·C KurataK Sakata
Nov 9, 2002·Autonomic Neuroscience : Basic & Clinical·Anthony L SicaPhyllis M Gootman
Feb 1, 1995·Australian and New Zealand Journal of Medicine·P W Kamen, A M Tonkin
Jun 25, 2005·The American Journal of Chinese Medicine·Chi-Hsien ChangGran-Hum Chen
Apr 17, 2007·American Journal of Physiology. Heart and Circulatory Physiology·A M D WatsonC N May
Aug 31, 2012·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jean C HardwickJeffrey L Ardell
Jul 17, 2009·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Jean C HardwickJeffrey L Ardell
Oct 24, 2012·Interdisciplinary Perspectives on Infectious Diseases·Diego F DávilaBarbara Das Neves
Oct 1, 1991·The American Review of Respiratory Disease·P D Snashall, K F Chung
Mar 26, 2005·Circulation Journal : Official Journal of the Japanese Circulation Society·Motoki NiheiItsuo Kodama
Dec 18, 2013·Autonomic Neuroscience : Basic & Clinical·Wohaib Hasan, Peter G Smith
Nov 14, 2013·Autonomic Neuroscience : Basic & Clinical·Jean C HardwickE Marie Southerland
Sep 25, 2014·Journal of the Neurological Sciences·Mary A WooRajesh Kumar

❮ Previous
Next ❯

Related Concepts

Trending Feeds


Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Epigenetics Insights from Twin Studies

Find the latest research on epigenetics and twin studies here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.


Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Regulation of Vocal-Motor Plasticity

Dopaminergic projections to the basal ganglia and nucleus accumbens shape the learning and plasticity of motivated behaviors across species including the regulation of vocal-motor plasticity and performance in songbirds. Discover the latest research on the regulation of vocal-motor plasticity here.

Myocardial Stunning

Myocardial stunning is a mechanical dysfunction that persists after reperfusion of previously ischemic tissue in the absence of irreversible damage including myocardial necrosis. Here is the latest research.