PMID: 9523931Apr 2, 1998Paper

Autonomic regulation of gastric ulcerogenesis after cervical cord transection in the rat

Academic Emergency Medicine : Official Journal of the Society for Academic Emergency Medicine
R D Waldrop, G M Strain

Abstract

To examine the role of anticholinergic and sympathomimetic drugs in preventing gastric ulcerogenesis after cervical cord transection (CCT) in the rat. A randomized, prospective, interventional trial was performed comparing pirenzepine (muscarinic type I receptor antagonist) and ephedrine (nonspecific sympathomimetic) in the prevention of gastric ulcerogenesis after CCT in the rat. After isoflurane-induced general anesthesia, group 1 (n = 12) received sham CCT with no pretreatment, group 2 received CCT with no pretreatment, group 3 received CCT with pirenzepine pretreatment (0.01/mg/kg IP), and group 4 received CCT with ephedrine pretreatment (3 mg/kg IP). Six hours after intervention, all the rats were euthanized with isoflurane, stomachs were dissected, and a gastric ulcer index was determined. The mean (+/- SD) ulcer index was 0.08 +/- 0.1 for group 1, 2.33 +/- 0.5 for group 2 (p = 0.01), 0.41 +/- 0.7 for group 3 (p = 0.037 compared with group 2), and 0.75 +/- 0.7 for group 4 (p = 0.0005 compared with group 2). Groups 3 and 4 were not significantly different from each other (p = 0.30). Gastric ulcerogenesis after CCT in the rat is decreased by anticholinergic and sympathomimetic drug pretreatment.

References

Sep 1, 1991·Brain Research. Brain Research Reviews·G B GlavinD E Hernandez
Aug 1, 1990·Journal of Pediatric Gastroenterology and Nutrition·J R Hamilton
Jan 1, 1990·Scandinavian Journal of Gastroenterology. Supplement·U Haglund
Jan 1, 1989·Journal of Clinical Gastroenterology·J W Freston
Jun 1, 1986·The Australian and New Zealand Journal of Surgery·D G MacLellanK J Hardy
Apr 1, 1971·Archives of Surgery·C E LucasA J Walt
Jan 1, 1981·Digestive Diseases and Sciences·H H Sigman, A Gillich
Sep 1, 1983·The Journal of Trauma·E FaistG Heberer
Sep 17, 1981·The New England Journal of Medicine·A S DetskyG E Thibault
Mar 1, 1981·World Journal of Surgery·L Y Cheung
Jan 1, 1993·Journal of Clinical Gastroenterology·Y Taché, M Yoneda

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Citations

Oct 22, 2005·Digestive Diseases and Sciences·George M Strain, Ron D Waldrop

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