Autonomic regulation of heart rate and QT interval in nonalcoholic cirrhosis with ascites

Digestion
C LazzeriF Franchi

Abstract

Autonomic neuropathy, as indicated by alterations in standard cardiovascular tests, is frequently encountered in cirrhosis. We investigated the autonomic modulation of the heart in nonalcoholic cirrhosis with ascites by evaluating the 24-hour heart rate variability (HRV), a powerful noninvasive tool to assess the sympathovagal balance of the heart. Low (LF) and high frequency (HF) components and their ratio, and time domain indexes of HRV were evaluated in 24-hour, daytime and nighttime periods in 12 patients and 12 healthy subjects, together with the conventional and dynamic QT interval. Cirrhotic patients had values of the mean RR interval and frequency domain indexes in the whole 24-hour period similar to those of healthy subjects, despite higher than normal plasma norepinephrine levels. Patients also showed lower LF and higher HF values than controls during the day, a reduction in time domain indexes, and no circadian rhythm of frequency domain indexes. QT parameters were similar in the 2 groups, but patients had a blunted QT rhythm and a reduced QT variability. Patients with nonalcoholic cirrhosis and ascites have an impaired autonomic regulation of the heart, which involves both the sympathetic and the parasympathetic bra...Continue Reading

Citations

Nov 5, 1999·Liver Transplantation and Surgery : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·B M ParkerJ E Tetzlaff
May 4, 2000·Pacing and Clinical Electrophysiology : PACE·C LazzeriF Franchi
Nov 22, 2008·American Journal of Physiology. Gastrointestinal and Liver Physiology·Ali R ManiMarsha Y Morgan
Nov 13, 2013·Nature Reviews. Gastroenterology & Hepatology·Signe WieseSøren Møller
Feb 13, 2009·Expert Review of Gastroenterology & Hepatology·Søren MøllerAleksander Krag
Apr 5, 2013·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Waqas QureshiFatima Khalid
Apr 7, 2015·Archives of Medical Research·Antonino TuttolomondoAntonio Pinto
May 14, 2010·Journal of Hepatology·Søren Møller, Jens H Henriksen
Apr 15, 2014·Korean journal of anesthesiology·In Young HuhGyu-Sam Hwang
Sep 21, 2004·World Journal of Gastroenterology : WJG·Katalin KeresztesFerenc Szalay
May 19, 2017·World Journal of Cardiology·Sun Moon KimAlison L Bailey
Mar 11, 2020·Medicina·Joice Anaize Tonon do AmaralAna Cristina Aoun Tannuri
Feb 21, 2019·Brazilian Journal of Medical and Biological Research = Revista Brasileira De Pesquisas Médicas E Biológicas·M V H CarvalhoV N Carvalho
Nov 18, 1998·Scandinavian Journal of Clinical and Laboratory Investigation·S Møller, J H Henriksen
Nov 15, 2020·Indian Journal of Gastroenterology : Official Journal of the Indian Society of Gastroenterology·N KapoorP Kar
Apr 16, 2021·Physiological Measurement·Tope OyeladeAli R Mani

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