PMID: 9188083May 12, 1997Paper

Autonomic response to change of posture among normal and mild-hypertensive adults: investigation by time-dependent spectral analysis

Journal of the Autonomic Nervous System
S AkselrodL Keselbrener

Abstract

In this study, we applied the time-dependent spectral analysis approach (SDA) to investigate the autonomic changes occurring during a transition from supine to standing position (CP), in normal and unmedicated mild hypertensive subjects. The SDA method enables an accurate follow-up of the instantaneous changes in autonomic activity, even during the unsteady phase of the transition, where sudden changes in heart rate (HR) and arterial blood pressure (ABP) are observed. We were able to quantify the vagal withdrawal (reflected in the high frequency component of the time-dependent spectrum of HR fluctuations) in the immediate response to CP and the more slowly following sympathetic increase (reflected in the low frequency component of ABP). This general pattern was observed in both groups. In addition, our results identified an altered sympathetic response to CP in mild-hypertensives, as compared to normal adults. Their basal sympathetic activity is enhanced (higher mean HR and increased low frequency fluctuations in ABP) and their response to CP is reduced, as reflected only in the LF content of ABP fluctuations, relative to normals. No difference was observed in HR fluctuations, showing that there is no parasympathetically mediat...Continue Reading

References

Apr 1, 1975·Circulation·A TakeshitaM Nakamura
Aug 1, 1991·Circulation·A MallianiS Cerutti
Nov 1, 1989·Journal of the American College of Cardiology·M L AppelR J Cohen
Sep 1, 1986·IEEE Transactions on Bio-medical Engineering·R D BergerR J Cohen
Dec 1, 1986·Computers and Biomedical Research, an International Journal·G BaselliM Pagani
Jul 1, 1985·Journal of Biomedical Engineering·R I KitneyD A Linkens
Jan 1, 1969·Circulation·J D BristowH S Smyth
Oct 1, 1971·Circulation Research·B GribbinR Peto
Feb 1, 1993·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·W WielingA M van Leeuwen
Oct 1, 1995·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L Keselbrener, S Akselrod
Dec 1, 1996·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L KeselbrenerS Akselrod
Jan 1, 1995·Clinical and Experimental Pharmacology & Physiology. Supplement·S EliashS Cohen

❮ Previous
Next ❯

Citations

Feb 7, 1998·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L KeselbrenerS Akselrod
Oct 12, 2000·Clinical Autonomic Research : Official Journal of the Clinical Autonomic Research Society·L KeselbrenerZ Rotstein
Apr 1, 2000·Journal of the Autonomic Nervous System·U GerhardtH Hohage
Jul 10, 2002·International Journal of Cardiology·Jiri PumprlaJames Nolan
Mar 31, 2000·Neurophysiologie clinique = Clinical neurophysiology·S SantiagoM L Espinosa
Jul 28, 2001·Autonomic Neuroscience : Basic & Clinical·S EyalS Akselrod
Aug 4, 2001·Autonomic Neuroscience : Basic & Clinical·S AkselrodA Baharav
Oct 30, 1998·Fundamental & Clinical Pharmacology·L HalmaiJ M Karemaker
Jan 13, 2006·IEEE Transactions on Bio-medical Engineering·Yael GorenSolange Akselrod
Feb 10, 2004·Journal of Applied Physiology·Tomi LaitinenJuha Hartikainen
Mar 24, 2004·Journal of Human Hypertension·R VirtanenJ Airaksinen
Jun 14, 2003·American Journal of Physiology. Heart and Circulatory Physiology·L R DavrathS Akselrod
Nov 10, 1998·Journal of Medical Engineering & Technology·S CarrascoJ Azpiroz
Nov 29, 2002·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Eran ToledoSolange Akselrod
Dec 20, 2005·American Journal of Physiology. Heart and Circulatory Physiology·Kaisu MartinmäkiJoni Kettunen
Dec 10, 1999·Journal of the American Society of Nephrology : JASN·M G BarnasH A Koomans

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.