Autonomic responses of blood vessels and sweat glands in patients with schizophrenia treated with olanzapine or clozapine

Psychopharmacology
M Mueck-WeymannM W Agelink

Abstract

Data comparing the in vivo effects on autonomic nervous system function of standard clinical doses of olanzapine and clozapine are sparse. The goal of this study was to compare the skin conductance response (which is peripherally mediated via muscarinic m3-receptors) and the inspiratory gasp response (which is peripherally mediated via adrenergic receptors) between healthy controls and schizophrenics treated with clozapine or olanzapine. Twenty patients with schizophrenia (according to DSM-III-R criteria) treated with either clozapine (200-500 mg/day) or olanzapine (10-20 mg/day) as well as ten matched controls underwent simultaneous recordings of the skin conductance response (SCR) of sweat glands and of the inspiratory gasp response (IGR) of acral blood vessels. A single, deep inspiration was used as the stimulus. Group differences for the SCR amplitudes and the post-IGR redilation times were compared using the Mann-Whitney test. Both clozapine- and olanzapine-treated patients showed a significant SCR reduction compared to controls. Interestingly, the reduction in SCR was significantly larger in the clozapine group compared to the olanzapine group (P<0.05). Moreover, only clozapine-treated patients showed a statistical trend ...Continue Reading

Citations

Nov 5, 2002·Depression and Anxiety·Michael Mueck-WeymannDominique Musselman
Dec 4, 2003·Progress in Neuro-psychopharmacology & Biological Psychiatry·Frank P BymasterDavid L Mckinzie
Jun 22, 2002·Clinical Physiology and Functional Imaging·M Mueck-Weymann, R Rauh
May 22, 2008·Brain : a Journal of Neurology·M HoeferH J Rosen
Oct 16, 2004·International Clinical Psychopharmacology·Klaus MannRalf W Dittmann
Jan 20, 2012·The American Journal of Dermatopathology·Ana María Molina-RuizLuis Requena
Sep 9, 2008·European Journal of Pharmacology·Zahra NourianTorsten Kristensen
May 24, 2011·Journal of Affective Disorders·Konstantinos N FountoulakisHagop Akiskal
Jun 29, 2016·International Journal of Cardiology·Ines PotočnjakMiro Jakovljević
Jul 9, 2008·The World Journal of Biological Psychiatry : the Official Journal of the World Federation of Societies of Biological Psychiatry·Young Sup WooWon-Myong Bahk
Feb 7, 2018·Journal of Ophthalmic & Vision Research·Vivian Wm HoStephen B Kaye

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