Autonomic responses to heartburn induced by esophageal acid infusion

Journal of Gastroenterology and Hepatology
Chien-Lin Chen, William C Orr

Abstract

Studies have shown that altered visceral perception and lower pain thresholds in patients with symptomatic gastroesophageal reflux disease (GERD) and non-cardiac chest pain. Autonomic changes associated with the perception of heartburn in patients with GERD are poorly understood. A total of 12 GERD patients (six male, six female; mean age 37.2 +/- 2.7 years) and 12 controls (five male, seven female; mean age 32.8 +/- 2.2 years) were studied. The study protocol included a 20-min water infusion (6 mL/min), and 20-min acid infusion (0.1 N HCl, 6 mL/min). Spectral analysis of heart-rate variability (HRV) was used to assess autonomic functioning. The measured HRV indices included the power in the low-frequency (LF) band (0.04-0.15 Hz) reflecting sympathetic tone, and power in the high-frequency (HF) band (0.15-0.5 Hz) reflecting vagal tone, and the LF/HF ratio as an indicator of sympathovagal balance. The GERD group experienced more heartburn than controls with acid infusion. Between-group comparisons showed no significant changes in LF band power in any period. The HF band power was significantly lower in GERD patients during all infusion periods. The LF/HF ratio was significantly larger in GERD patients. The perception of heartbur...Continue Reading

References

Jun 1, 1990·Gastroenterology·W E WhiteheadM M Schuster
Jan 1, 1986·Journal of Clinical Gastroenterology·L F Johnson, T R DeMeester
Oct 1, 1986·Gastroenterology·J E RichterD O Castell
Feb 1, 1997·Clinical Science·G TougasA R Upton
Apr 15, 1999·Canadian Journal of Gastroenterology = Journal Canadien De Gastroenterologie·G Tougas

❮ Previous
Next ❯

Citations

Sep 16, 2010·Psychosomatic Medicine·Abhishek SharmaQasim Aziz
Feb 9, 2013·Digestive Diseases and Sciences·Chien-Lin ChenTso-Tsai Liu
Oct 15, 2013·The American Journal of Medicine·Gagan D SinghEzra A Amsterdam
Sep 12, 2012·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·Luca MieleAntonio Grieco
Dec 4, 2010·Best Practice & Research. Clinical Gastroenterology·Y C Chua, Qasim Aziz
Jan 25, 2007·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·K C CainM M Heitkemper
Jun 8, 2012·Neurogastroenterology and Motility : the Official Journal of the European Gastrointestinal Motility Society·A SharmaQ Aziz
Jun 8, 2012·Neurourology and Urodynamics·Jiunn-Horng KangHerng-Ching Lin
Oct 15, 2013·Annals of the New York Academy of Sciences·Philip WoodlandAdam D Farmer
Jun 23, 2009·European Journal of Pain : EJP·Christina BrockAsbjørn Mohr Drewes
Aug 30, 2006·Scandinavian Journal of Gastroenterology·Chien-Lin ChenTerry B J Kuo
Nov 5, 2021·Acta otorhinolaryngologica Italica : organo ufficiale della Società italiana di otorinolaringologia e chirurgia cervico-facciale·Yang XuGeoffrey Liu

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.