PMID: 18202530Jan 19, 2008Paper

Autonomously functioning thyroid nodule associated with thyrotoxic periodic paralysis

Endocrine Journal
Hiroshi OzakiKatsumi Yoshida

Abstract

Thyrotoxic periodic paralysis (TPP) is mainly associated with Graves' disease but rarely with autonomously functioning thyroid nodule (AFTN). We herein report a case of AFTN associated with TPP in which the latter resolved after (131) I therapy for the former. We analyzed the genes encoding thyrotropin receptor (TSHR), the alpha-subunit of the stimulatory G protein (Gsalpha), calcium channel CACNA1S and potassium channel KCNE3, and found that the patient does not carry the known mutations in these genes. Whereas the pathogenesis of TPP and AFTN remains to be understood, the present case suggests that ion channel defects responsible for familial hypokalemic periodic paralysis may not be associated with TPP, and that mutations in TSHR and Gs alpha genes may be less frequent in AFTN patients in the Japanese population.

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Citations

Aug 25, 2012·Endocrine·Henrik FalhammarJan Calissendorff
Apr 4, 2014·Journal of Thyroid Research·Abhishek VijayakumarDurganna Thimmappa
Jan 22, 2010·Journal of Intensive Care Medicine·Pooja Pothiwala, Steven N Levine
Jul 13, 2012·Journal of Korean Medical Science·Sang Bo OhIn Joo Kim

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