Autophagic fungal cell death is necessary for infection by the rice blast fungus

Science
Claire Veneault-FourreyNicholas J Talbot

Abstract

Rice blast is caused by the fungus Magnaporthe grisea, which elaborates specialized infection cells called appressoria to penetrate the tough outer cuticle of the rice plant Oryza sativa. We found that the formation of an appressorium required, sequentially, the completion of mitosis, nuclear migration, and death of the conidium (fungal spore) from which the infection originated. Genetic intervention during mitosis prevented both appressorium development and conidium death. Impairment of autophagy, by the targeted mutation of the MgATG8 gene, arrested conidial cell death but rendered the fungus nonpathogenic. Thus, the initiation of rice blast requires autophagic cell death of the conidium.

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Citations

May 24, 2013·Applied Microbiology and Biotechnology·Benjamin M NitscheArthur F J Ram
Oct 1, 2013·Applied Microbiology and Biotechnology·Oliver Voigt, Stefanie Pöggeler
Mar 15, 2012·Histochemistry and Cell Biology·Markus IslingerMichael Schrader
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Mar 19, 2013·PloS One·Colin P De SouzaStephen A Osmani

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