PMID: 9184851May 1, 1997Paper

Autophagic proteolysis: control and specificity

The Histochemical Journal
E F BlommaartAlfred J Meijer

Abstract

The rate of proteolysis is an important determinant of the intracellular protein content. Part of the degradation of intracellular proteins occurs in the lysosomes and is mediated by macroautophagy. In liver, macroautophagy is very active and almost completely accounts for starvation-induced proteolysis. Factors inhibiting this process include amino acids, cell swelling and insulin. In the mechanisms controlling macroautophagy, protein phosphorylation plays an important role. Activation of a signal transduction pathway, ultimately leading to phosphorylation of ribosomal protein S6, accompanies inhibition of macroautophagy. Components of this pathway may include a heterotrimeric Gi3-protein, phosphatidylinositol 3-kinase and p70S6 kinase. Recent evidence indicates that lysosomal protein degradation can be selective and occurs via ubiquitin-dependent and -independent pathways.

Citations

Dec 16, 1998·The Journal of Clinical Endocrinology and Metabolism·E VolpiP De Feo
Aug 13, 1999·The American Journal of Physiology·M Desautels, S Heal
Mar 21, 2000·Journal of Cellular Biochemistry·C J LynchS R Kimball
Jun 28, 2000·Current Opinion in Clinical Nutrition and Metabolic Care·P Costelli, F M Baccino
Aug 3, 2002·European Journal of Biochemistry·Ulrike KrauseLouis Hue
May 29, 2003·The Journal of Nutrition·Alfred J Meijer
Sep 3, 2003·Cell Structure and Function·Makoto TsuneokaAkitsugu Yamamoto
Jul 24, 2004·The Journal of Biological Chemistry·Hiroshi AkazawaIssei Komuro
Feb 18, 2005·The Journal of Biological Chemistry·Padmanabhan Anand, Philip A Gruppuso
Feb 25, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Wilfried BurschRolf Schulte-Hermann
Nov 22, 2005·Acta Pharmacologica Sinica·Ya-Ping YangZheng-Hong Qin
Mar 3, 2007·Leukemia·A ErtmerH M Schätzl
Jun 4, 2008·Journal of Neuroscience Research·Seok Hwan KimNatik Piri
May 16, 2009·Journal of the American Society of Nephrology : JASN·Yuji SekineKunimasa Yan
Jul 29, 2010·Physiological Reviews·Harmeet MalhiGregory J Gores
Apr 3, 2012·Cellular Microbiology·Feng-Jun LiCynthia Y He
Apr 1, 2014·Apoptosis : an International Journal on Programmed Cell Death·Xin LvHonghui Lin
May 23, 2015·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Kristof De Schutter, Els J M Van Damme
Mar 11, 2016·Journal of Dental Research·Y LiJ Liu
Sep 3, 1999·Molecular Biology of the Cell·M HorstP V Schu
Jul 11, 2001·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·A DonatiE Bergamini
Jul 16, 2002·Canadian Journal of Physiology and Pharmacology·Bita Moazed, M Desautels
Oct 14, 2004·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Charlotte HinaultEmmanuel Van Obberghen
Oct 19, 2004·FEMS Yeast Research·Wilfried Bursch
Aug 4, 2006·Journal of the American Society of Nephrology : JASN·Wen ShenHarold A Franch
Sep 15, 2006·Ultrastructural Pathology·Mauricio Orozco-LeviJoaquim Gea
Jun 10, 2010·Human Molecular Genetics·Cara RothenbergMervyn J Monteiro
Jan 4, 2012·Cellular Microbiology·Debasish GhoshAnthony P Sinai
Feb 1, 2013·Journal of Pineal Research·Seung-Il ChoiEung Kweon Kim
Jun 2, 2014·Amino Acids·Alfred J MeijerPatrice Codogno
Jan 1, 2016·American Journal of Physiology. Lung Cellular and Molecular Physiology·Saket AhujaPoornima Mahavadi
Nov 29, 2017·Experimental & Applied Acarology·Nicole O Moura-MartinianoCarlos Augusto Gomes Soares
Mar 22, 2003·Circulation Research·Sawa KostinJutta Schaper
Feb 11, 2003·Cell Structure and Function·Noboru MizushimaTamotsu Yoshimori
Mar 30, 2004·Plant & Cell Physiology·Chihiro TakatsukaYuji Moriyasu

❮ Previous
Next ❯

Related Concepts

Related Feeds

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.