Autophagosomal protein dynamics and influenza virus infection.

Frontiers in Immunology
Verónica I Dumit, Jörn Dengjel

Abstract

Autophagy is a constitutive, catabolic process leading to the lysosomal degradation of cytosolic proteins and organelles. However, it is also induced under stress conditions, remodeling the eukaryotic cell by regulating energy, protein, and lipid homeostasis. It is likely that the autophagosomal/lysosomal pathway evolved primordially to recycle cell components, but further functionally developed as to become part of the immune system to defend against invading pathogens. Likewise, pathogenic, foreign agents developed strategies to fight back and even to employ the autophagy machinery to their own benefit. Hence, the regulation of autophagy has many implications on human health and disease. This review summarizes the molecular dynamics of autophagosome formation, maturation, and target selection. Membrane dynamics, as well as protein-protein and protein-membrane interactions are particularly addressed. In addition, it recapitulates current knowledge of the influences of influenza virus infection on the process.

Citations

Mar 26, 2014·American Journal of Respiratory Cell and Molecular Biology·David R HahnTimothy E Weaver
Feb 6, 2014·The Journal of Investigative Dermatology·Verónica I DumitJörn Dengjel
May 7, 2015·Autophagy·Miguel A Martín-AcebesJuan-Carlos Saiz
Nov 28, 2013·Autophagy·Kristoffer Tg RigboltJörn Dengjel
Jun 9, 2015·Frontiers in Microbiology·Jun-Da ZhuHwa-Chain R Wang
Dec 3, 2014·Antiviral Research·Hai-yan ZhuMei-qing Feng
May 28, 2016·BMC Cell Biology·Jegan IyyathuraiGeert Bultynck
Nov 13, 2013·Innate Immunity·Shweta TripathiKevan L Hartshorn
Feb 23, 2019·Viruses·Robert MeinekeHusni Elbahesh
Mar 1, 2018·Frontiers in Microbiology·Yupeng WangChan Ding
Jul 12, 2019·JCI Insight·Candice A SmithDaniel R Goldstein

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Methods Mentioned

BETA
electron microscopy
ubiquitination
lipidation

Software Mentioned

MultiProt Server
VMD

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